Significance of Clostridium difficile and its cytotoxin in children
Significance of Clostridium difficile and its cytotoxin in children
复制标题
艰难梭菌及其细胞毒素对儿童的意义
DOI：
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发表时间：
1986
影响因子：
3.6
通讯作者：
Jozef Vandepitte
中科院分区：
文献类型：
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作者：
V. Merida;J. Moerman;J. Colaert;P. Lemmens;Jozef Vandepitte
对147名不同年龄组儿童的粪便进行了艰难梭菌及其细胞毒素和其他肠道病原体的检查。31例足月新生儿、32例早产儿、59例婴儿和25例大龄儿童中分别有5例（16%）、27例（46%）和1例（4%）检出C。在他们的粪便中艰难。仅在4名婴儿（7%）中检测到粪便细胞毒素。这与腹泻、先前的抗生素治疗、饮食类型或其他肠道病原体的伴随存在没有相关性。艰难梭菌可能是从环境来源获得的，不能被视为儿童腹泻的重要原因。
Stools of 147 children belonging to different age groups were examined for the presence of Clostridium difficile, its cytotoxin and other enteric pathogens. None of the 31 full-term neonates, 5 (16%) of the 32 premature neonates, 27 (46%) of the 59 infants and 1 (4%) of the 25 older children excreted C. difficile in their stools. Faecal cytotoxin was only detected in four infants (7%). There was no correlation with diarrhoea, previous antibiotic therapy, type of diet, or the concomitant presence of other intestinal pathogens.We conclude that colonisation of the intestine by C. difficile is probably acquired from environmental sources and that it cannot be regarded as a significant cause of diarrhoea in children.