Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity
Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity
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DOI：
10.1191/0960327102ht213oa
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发表时间：
2002-02-01
影响因子：
2.8
通讯作者：
Barrett, JC
中科院分区：
文献类型：
--
作者：
Martin, KR;Barrett, JC
RO在生物系统中种类繁多，含量丰富。虽然过量的ROS产生明显损害DNA，但低水平的ROS会影响细胞信号，特别是在氧化还原调节水平上。此外，ROS在维持细胞数量动态平衡中对细胞凋亡和有丝分裂的具体作用还有待阐明。ROS剂量是决定最终细胞反应的关键参数；然而，剂量反应曲线的形状是不可预测的。当细胞受到ROS刺激时，细胞信号级联被激活。细胞氧化还原电位似乎是细胞功能的重要决定因素，氧化还原平衡的中断可能会对细胞功能产生不利影响。因此，抗氧化剂等化合物可以拦截关键的ROS信号分子，既保护细胞，又促进发病。因此，需要进一步研究ROS在氧化还原调节中的作用以及抗氧化剂对细胞反应的潜在结果。
ROS are diverse and abundant in biological systems. While excessive ROS production clearly damages DNA, low levels of ROS affect cell signaling particularly at the level of redox modulation. Moreover, the specific contributions of ROS to apoptosis and mitogenesis in maintenance of cell number homeostasis remains to be elucidated. ROS dose is a critical parameter in determining the ultimate cellular response; however the shape of the dose response curve is unpredictable. When cells are stimulated with ROS, cell-signaling cascades are activated. It appears that the cellular redox potential is an important determinant of cell function and interruption of redox balance may adversely affect cell function. As a result, compounds such as antioxidants may intercept critical ROS signaling molecules and both protect cells and foster pathogenesis. As a result, further study is needed to unravel the role of ROS in redox regulation and the potential outcome of antioxidant administration on cellular responses.