The effects of interferon beta treatment on arthritis
The effects of interferon beta treatment on arthritis
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DOI：
10.1093/rheumatology/38.4.362
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发表时间：
1999-04-01
期刊：
影响因子：
5.5
通讯作者：
Breedveld, FC
中科院分区：
文献类型：
--
作者：
Tak, PP;'t Hart, BA;Breedveld, FC
目标。为了确定干扰素-β治疗对关节炎是否有益处，我们评估了干扰素-β对猕猴II型胶原诱导的关节炎(CIA)的影响，并在类风湿关节炎(RA)患者中进行了初步研究。用10×10(6)U(MIU)/kg哺乳动物细胞来源的重组干扰素-β(Rebif(R)；Ares-Serono)S.C.治疗4只CIA-猕猴。每日一次，为期一周。随后，12例活动期RA患者接受纯化的天然成纤维细胞干扰素-β(Frone(R)，Ares-Serono)S.C.治疗12周。每周3次，剂量分别为6MIU(n=4)、12MIU(n=4)和18MIU(n=4)。在四只患有CIA的恒河猴中，有三只在干扰素-β治疗过程中观察到临床症状迅速改善。在所有猴子停止治疗后，血清C-反应蛋白(CRP)水平也显著下降，随后又上升。完成研究的10名RA患者平均表现出关节压痛和肿胀计数、患者对疼痛的评估以及患者和医生的总体评估的逐渐改善(均P<；0.05)。健康评估问卷和血清CRP水平也有下降的趋势，但没有统计学意义；治疗12周后，40%的患者达到了ACR标准，改善了20%，而没有患者达到了ACR标准，改善了50%。未发现明显的剂量-反应关系。这些数据表明，干扰素-β治疗对关节炎有有益的效果。
Objective. To determine whether interferon beta (IFN-beta) therapy might have a beneficial effect on arthritis, we evaluated the effect of IFN-beta on collagen type II-induced arthritis (CIA) in rhesus monkeys and conducted a pilot study in patients with rheumatoid arthritis (RA).Methods. Four rhesus monkeys with CIA-were treated with 10 x 10(6) U(MIU)/kg mammalian cell-derived recombinant IFN-beta (Rebif(R); Ares-Serono) s.c. daily for 1 week. Subsequently, 12 patients with active RA were treated for 12 weeks with purified natural fibroblast IFN-beta (Frone(R), Ares-Serono) s.c. 3 times weekly at the following dosages: 6 MIU (n = 4), 12 MIU (n = 4) and 18 MIU (n = 4).Results. Rapid clinical improvement during IFN-beta therapy was observed in three of the four rhesus monkeys with CIA. There was also a marked decrease in serum C-reactive protein (CRP) levels with a subsequent increase after discontinuation of the treatment in all monkeys. The 10 RA patients who completed the study exhibited on average gradual improvement of tender and swollen joint counts, patient's assessment of pain, and patient's and doctor's global assessment (all P < 0.05). The health assessment questionnaire and serum CRP levels also tended to decrease, but this was not statistically significant; 40% of the patients fulfilled the ACR criteria for 20% improvement, whereas none fulfilled the ACR criteria for 50% improvement 12 weeks after initiation of treatment. There was no clear dose-response relationship.Conclusion. The data suggest that IFN-beta treatment has a beneficial effect on arthritis.