Macroindentation hardness measurement-Modernization and applications
Macroindentation hardness measurement-Modernization and applications
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DOI：
10.1016/j.ijpharm.2016.04.068
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发表时间：
2016-06-15
影响因子：
5.8
通讯作者：
Sun, Changquan Calvin
中科院分区：
文献类型：
--
作者：
Patel, Sarsvat;Sun, Changquan Calvin
在这项研究中，我们首先开发了一种现代化的压痕技术用于测量片剂硬度。该技术的特点是快速的数字图像捕获，使用校准的光学显微镜，和精确的面积测定。然后，我们系统地研究了关键的实验参数，包括压痕力，速度和保持时间，测量硬度的一个非常软的材料，羟丙基纤维素，和一个非常硬的材料，磷酸氢钙，覆盖范围广泛的材料性能的影响。根据试验结果，建议在峰值压入载荷下保持3 min，以尽量减少试验速度对H的影响。使用这种方法，我们表明，一个指数衰减函数很好地描述了片剂硬度和孔隙率之间的关系，在这项工作中研究的七种常用的药物粉末。我们建议，H和H在零孔隙率可用于量化片剂的变形性和粉末的可塑性，分别。(c)© 2016 Elsevier B.V.版权所有。
In this study, we first developed a modernized indentation technique for measuring tablet hardness. This technique is featured by rapid digital image capture, using a calibrated light microscope, and precise area-determination. We then systematically studied effects of key experimental parameters, including indentation force, speed, and holding time, on measured hardness of a very soft material, hydroxypropyl cellulose, and a very hard material, dibasic calcium phosphate, to cover a wide range of material properties. Based on the results, a holding period of 3 min at the peak indentation load is recommended to minimize the effect of testing speed on H. Using this method, we show that an exponential decay function well describes the relationship between tablet hardness and porosity for seven commonly used pharmaceutical powders investigated in this work. We propose that H and H at zero porosity may be used to quantify the tablet deformability and powder plasticity, respectively. (c) 2016 Elsevier B.V. All rights reserved.