EFFECTS OF CORTICOTROPIN-RELEASING FACTOR AND GROWTH HORMONE-RELEASING FACTOR ON SLEEP AND ACTIVITY IN RATS
EFFECTS OF CORTICOTROPIN-RELEASING FACTOR AND GROWTH HORMONE-RELEASING FACTOR ON SLEEP AND ACTIVITY IN RATS
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DOI：
10.1159/000124489
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发表时间：
1986-04-01
影响因子：
4.1
通讯作者：
HENRIKSEN, SJ
中科院分区：
文献类型：
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作者：
EHLERS, CL;REED, TK;HENRIKSEN, SJ
本实验观察了成年雄性大鼠侧脑室注射促肾上腺皮质激素释放因子（CRF）和生长激素释放因子（GRF）后对脑电图（EEC）和睡眠觉醒行为体征的影响。EEG记录的视觉评分以及频谱分析显示，CRF（0.0015-0.015 nmol）引起慢波睡眠减少，伴随着低频（1-6 Hz）频谱功率的显著降低和高频（32-64 Hz）的增加。与此相反，GRF（2.0 nmol）产生增加的EEG和慢波睡眠的行为体征，与低频（1-2 Hz）频谱功率的显著增加和高频（32-64 Hz）的降低相关。在大鼠昼夜节律周期的活动部分给药时，还发现ICV给药GRF会减少运动。CRF和GRF后观察到的这些EEG和行为结果与大鼠和人类睡眠-觉醒周期期间皮质类固醇和生长激素释放的已知昼夜节律时间相关的行为一致。
The effects of corticotropin-releasing factor (CRF) and growth hormone-releasing factor (GRF) on electroencephalographic (EEC) and behavioral signs of sleep and wakefulness following intracerebroventricular (ICV) administration was investigated in adult male rats. Visual scoring of EEG records as well as spectral analysis revealed that CRF (0.0015-0.015 nmol) produced decreases in slow wave sleep concomitant with significant decreases in spectral power in lower frequencies (1-6 Hz) and increases in high frequencies (32-64 Hz). In contrast, GRF (2.0 nmol) produced increased EEG and behavioral signs of slow wave sleep associated with significant increases in spectral power in the low frequencies (1-2 Hz) and decreases in high frequencies (32-64 Hz). ICV administration of GRF was also found to produce decreases in locomotion when administered during the active part of the rats'' circadian cycle. These EEG and behavioral findings seen following CRF and GRF are consistent with the behaviors frequently correlated with the known circadian timing of the release of corticosteroids and growth hormone during the sleep-waking cycle in rat and human.