Development of inactivated trivalent vaccine for the teratogenic Aino, Akabane and Chuzan viruses
Development of inactivated trivalent vaccine for the teratogenic Aino, Akabane and Chuzan viruses
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DOI：
10.1016/j.biologicals.2011.02.004
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发表时间：
2011-05-01
期刊：
影响因子：
1.7
通讯作者：
Park, Chang
中科院分区：
文献类型：
--
作者：
Kim, Yeon-Hee;Kweon, Chang-Hee;Park, Chang
Aino、Akabane和Chuzan病毒是由节肢动物传播的(Arbo)病毒，由蚊子和库蚊等吸血昆虫传播。这些虫媒病毒感染主要与妊娠牛、绵羊和山羊的流产、死产和先天缺陷有关，给畜牧业造成了相当大的经济损失。这些病毒似乎广泛分布在东南亚和澳大利亚。作为控制策略，以二元乙亚胺或福尔马林为灭活剂，研制了Aino、Akabane和Chuzan病毒三价灭活疫苗。新开发的三价疫苗在小鼠、豚鼠和牛等动物身上进行了安全性和免疫原性评估。二次免疫后2周内即可检测到明显的免疫应答，未见任何副作用。由于实验疫苗的现场应用也显示了接种牛的抗体增加，我们证明了这些三价疫苗可以作为疫苗用于控制反刍动物的虫媒病毒感染。皇冠版权(C)2011由爱思唯尔有限公司代表国际生物制品联盟出版。版权所有。
Aino, Akabane and Chuzan viruses are arthropod-borne (arbo) viruses transmitted by blood-sucking insects like mosquitoes and Culicoides biting midges. These arbovirus infections are mainly associated with abortion, stillbirth and congenital defects in pregnant cattle, sheep and goats, which induces a considerable economic loss in livestock industry. The viruses seem to be widely distributed in Southeast Asia and Australia. As a control strategy, an inactivated trivalent vaccine against Aino, Akabane and Chuzan virus was developed by using binary ethylenimine or formalin as an inactivating agent. The newly developed trivalent vaccine is evaluated for its safety and immunogenicity in animals such as mice, guinea pigs and cattle. The immune responses were significantly detected within 2-weeks after second vaccination without any side effects. Since the field application of experimental vaccine also revealed increased antibodies in inoculated cattle, we demonstrated that these trivalent vaccines could be used as a vaccine to control the arboviral infections in ruminants. Crown Copyright (C) 2011 Published by Elsevier Ltd on behalf of The International Alliance for Biologicals. All rights reserved.