Relationship between impaired myocardial blood flow by positron emission tomography and low-attenuation plaque burden and pericoronary adipose tissue attenuation from coronary computed tomography: From the prospective PACIFIC trial.
Relationship between impaired myocardial blood flow by positron emission tomography and low-attenuation plaque burden and pericoronary adipose tissue attenuation from coronary computed tomography: From the prospective PACIFIC trial.
复制标题
正电子发射断层扫描导致的心肌血流受损与冠状动脉计算机断层扫描的低衰减斑块负荷和冠周脂肪组织衰减之间的关系：来自前瞻性 PACIFIC 试验。
DOI：
10.1007/s12350-022-03194-z
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Tam
中科院分区：
文献类型：
--
作者：
Kuronuma,Keiichiro;vanDiemen,PepijnA;Han,Donghee;Lin,Andrew;Grodecki,Kajetan;Kwiecinski,Jacek;Motwani,Manish;McElhinney,Priscilla;Tomasino,GuadalupeFlores;Park,Caroline;Kwan,Alan;Tzolos,Evangelos;Klein,Eyal;Shou,Benjamin;Tam
背景正电子发射断层扫描（PET）是临床定量心肌血流量（MBF）的金标准。冠状动脉周围脂肪组织（PCAT）衰减可以间接检测血管炎症。我们研究了PET和斑块负荷和PCAT对冠状动脉CT angiography（CCTA）的MBF之间的关系。MethodsThis事后分析的PACIFIC试验包括208例疑似冠状动脉疾病（CAD）进行[15 O]H2O PET和CCTA。结果在582支血管中，211支（36.3%）的每支血管充血性MBF受损（≤ 2.30mL/min/g）。在多变量分析中，动脉负荷与充血性MBF受损（P= 0.016）独立且一致相关;超过NCP负荷（P= 0.997）。在具有CAD严重程度和钙化斑块负荷的模型中，增加冠脉负荷改善了充血性MBF受损的预测性能（P< 0.001）。PCAT衰减与充血MBF之间无相关性（r=-0.11），在所有血管的单变量或多变量分析中，PCAT衰减与充血MBF受损无关（P> 0.1.ConclusionIn stable CAD patients，PCAT负荷与充血MBF受损独立相关，并且比NCP负荷更能预测充血MBF受损。PCAT衰减与充血MBF之间无相关性。
BackgroundPositron emission tomography (PET) is the clinical gold standard for quantifying myocardial blood flow (MBF). Pericoronary adipose tissue (PCAT) attenuation may detect vascular inflammation indirectly. We examined the relationship between MBF by PET and plaque burden and PCAT on coronary CT angiography (CCTA).MethodsThis post hoc analysis of the PACIFIC trial included 208 patients with suspected coronary artery disease (CAD) who underwent [15O]H2O PET and CCTA. Low-attenuation plaque (LAP, < 30HU), non-calcified plaque (NCP), and PCAT attenuation were measured by CCTA.ResultsIn 582 vessels, 211 (36.3%) had impaired per-vessel hyperemic MBF (≤ 2.30 mL/min/g). In multivariable analysis, LAP burden was independently and consistently associated with impaired hyperemic MBF (P= 0.016); over NCP burden (P= 0.997). Addition of LAP burden improved predictive performance for impaired hyperemic MBF from a model with CAD severity and calcified plaque burden (P< 0.001). There was no correlation between PCAT attenuation and hyperemic MBF (r= − 0.11), and PCAT attenuation was not associated with impaired hyperemic MBF in univariable or multivariable analysis of all vessels (P> 0.1).ConclusionIn patients with stable CAD, LAP burden was independently associated with impaired hyperemic MBF and a stronger predictor of impaired hyperemic MBF than NCP burden. There was no association between PCAT attenuation and hyperemic MBF.