The motility of mollicutes.
The motility of mollicutes.
复制标题
软体的运动性。
DOI：
10.1016/s0006-3495(03)74523-8
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发表时间：
2003
影响因子：
3.4
通讯作者：
Oster,George
中科院分区：
文献类型：
--
作者：
Wolgemuth,CharlesW;Igoshin,Oleg;Oster,George
最近的实验表明，丝蛋白的构象在许多不同类型的细菌的运动和形态中起作用。蛋白质亚基的构象变化可以产生驱动推进和细胞分裂的力。在这里，我们提出了一个分子机制，这些力量可以驱动细胞运动。生物化学循环（例如ATP水解）与弹性细丝的动力学的耦合使得弹性细丝能够传播产生推进力的变形。我们证明了两类无壁细菌（称为柔膜菌）的这种可能性：螺旋形螺原体的游动和支原体的滑行运动。
Recent experiments show that the conformation of filament proteins play a role in the motility and morphology of many different types of bacteria. Conformational changes in the protein subunits may produce forces to drive propulsion and cell division. Here we present a molecular mechanism by which these forces can drive cell motion. Coupling of a biochemical cycle, such as ATP hydrolysis, to the dynamics of elastic filaments enable elastic filaments to propagate deformations that generate propulsive forces. We demonstrate this possibility for two classes of wall-less bacteria called mollicutes: the swimming of helical-shapedSpiroplasma, and the gliding motility ofMycoplasma.