Rapid measurements of diastolic intramyocardial vascular volume.
Rapid measurements of diastolic intramyocardial vascular volume.
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快速测量舒张期心肌内血管容量。
DOI：
10.1152/ajpheart.1993.265.4.h1038
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Yin,FC
中科院分区：
文献类型：
--
作者：
Judd,RM;Resar,JR;Yin,FC
快速测量冠状血管容量对于完全了解冠状动脉血流是必要的。由于没有标准方法能够进行这些测量，我们开发了一种使用数字减影血管造影术对血管内造影剂进行成像的方法。该方法可在33 ms内测量血管体积，每秒可重复3次。该方法首先在幽灵中得到验证。然后，我们用这种方法测量了分离的、全氟化学灌注的犬室间隔的冠状动脉血管体积。测量的速度使我们第一次能够直接测量灌注压力突然变化后血管体积的瞬变。在稳态和最大血管舒张状态下，冠状动脉血管体积从灌注压力为20mmhg时的7.5 +/- 1.2 (SE) ml/ 100g变化到90mmhg时的12.1 +/- 1.9 ml/ 100g，这与其他报道相似。灌注压突然改变40 mmHg后，血管体积变化时间常数为3.2 +/- 0.3 (SE) s。增加心室壁拉伸对稳态体积（P = 0.25）和体积变化时间常数均无影响（P = 0.17）。时间常数比心脏周期长，但比使用其他方法测量血管体积所需的时间短得多，这一事实突出了快速测量血管体积的必要性。
Rapid measurements of coronary vascular volume are necessary for a complete understanding of phasic coronary flow. Because no standard method is capable of making these measurements, we developed a method that uses digital subtraction angiography to image an intravascular contrast agent. The method is capable of measuring vascular volume in 33 ms and can be repeated three times per second. The method was first validated in phantoms. We then used this method to measure coronary vascular volume in the isolated, perfluorochemical-perfused, interventricular canine septum. The speed of the measurements allowed us, for the first time, to directly measure transients in vascular volume following sudden changes in perfusion pressure. At the steady-state and maximal vasodilation, coronary vascular volume varied from 7.5 +/- 1.2 (SE) ml/100 g at a perfusion pressure of 20 mmHg to 12.1 +/- 1.9 ml/100 g at 90 mmHg, which is similar to other reports. After a sudden change of 40 mmHg in perfusion pressure, vascular volume changed with a time constant of 3.2 +/- 0.3 (SE) s. Increasing ventricular wall stretch had no effect on either the steady-state volumes (P = 0.25) or the time constant for volume changes (P = 0.17). The fact that the time constant is longer than the cardiac cycle, yet much shorter than the time necessary to measure vascular volume using other methods, highlights the need for rapid measurements of vascular volume.