Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment.
Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment.
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DOI:
10.1016/j.canlet.2015.10.022
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发表时间:
2016-09-28
期刊:
影响因子:
9.7
通讯作者:
Lin PC
中科院分区:
文献类型:
--
作者:
Qu P;Wang LZ;Lin PC
Myeloid derived suppressor cells (MDSCs) are a group of immature myeloid cells accumulated in most cancer patients and mouse tumor models. MDSCs suppress host immune response and concurrently promote tumor angiogenesis, thereby promote tumor growth and progression. In this review, we discuss recent progresses in expansion and activity of tumor MDSCs, and describe new findings about immunosuppressive function of different subtypes of MDSCs in cancer. We also discussed tumor angiogenic activities and pro-tumor invasion/metastatic roles of MDSCs in tumor progression.
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