Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment.

Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment.
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DOI:
10.1016/j.canlet.2015.10.022
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发表时间:
2016-09-28
期刊:
影响因子:
9.7
通讯作者:
Lin PC
Lin PC
中科院分区:
医学1区
文献类型:
--
作者:
Qu P;Wang LZ;Lin PC

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髓源性抑制细胞(MDSC)是在大多数癌症患者和小鼠肿瘤模型中积累的一组未成熟的骨髓细胞。MDSC抑制宿主免疫应答,同时促进肿瘤血管生成,从而促进肿瘤生长和进展。本文综述了近年来MDSCs在肿瘤中的扩增和活性研究进展,并对不同亚型MDSCs在肿瘤中的免疫抑制功能进行了描述。我们还讨论了肿瘤血管生成活性和促肿瘤侵袭/转移MDSC在肿瘤进展中的作用。
Myeloid derived suppressor cells (MDSCs) are a group of immature myeloid cells accumulated in most cancer patients and mouse tumor models. MDSCs suppress host immune response and concurrently promote tumor angiogenesis, thereby promote tumor growth and progression. In this review, we discuss recent progresses in expansion and activity of tumor MDSCs, and describe new findings about immunosuppressive function of different subtypes of MDSCs in cancer. We also discussed tumor angiogenic activities and pro-tumor invasion/metastatic roles of MDSCs in tumor progression.
癌症扩增的骨髓源性抑制细胞通过膜结合 TGF-β1 诱导 NK 细胞无反应。
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