The role of vaccination in rabies prevention
The role of vaccination in rabies prevention
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DOI：
10.1016/j.coviro.2012.03.007
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发表时间：
2012-06-01
影响因子：
5.9
通讯作者：
Briggs, Deborah J.
中科院分区：
文献类型：
--
作者：
Briggs, Deborah J.
狂犬病疫苗由 Louis Pasteur 及其同事于 1885 年开发的第一批粗制神经组织疫苗演变而来。目前，用于人类和动物的安全有效的狂犬病疫苗是在多种细胞培养系统中生产的，采用 WHO 和/或 ACIP 推荐的 10 种疫苗方案，用于人类暴露前和暴露后预防。狂犬病疫苗是减少狗狂犬病战略的关键组成部分，全球 98% 的人类狂犬病死亡是由狗狂犬病引起的。然而，如果没有跨部门方法，包括动物和人类健康专家之间的合作，就不可能消除储存动物物种中的狂犬病。迫切需要在监测有限甚至不存在的地区建立国家风险评估系统。
Rabies vaccines have evolved from the first crude nerve tissue vaccines developed by Louis Pasteur and his colleagues in 1885. Currently, safe and efficacious rabies vaccines for humans and animals are produced in several cell culture systems with 10 vaccine regimens recommended by WHO and/or ACIP for pre-exposure and post-exposure prophylaxis in humans. Rabies vaccines are a critical component in the strategy to reduce the dog rabies, the cause of 98% of all global human rabies deaths. However, eliminating rabies in the reservoir animal species is not possible without an intersectoral approach including collaboration between animal and human health experts. There is an urgent need to establish national risk assessment systems in regions where surveillance is limited to non-existent.