Topography of striate-extrastriate connections in neonatally enucleated rats.
Topography of striate-extrastriate connections in neonatally enucleated rats.
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新生去核大鼠纹状体与纹状体外连接的地形图。
DOI：
10.1155/2013/592426
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发表时间：
2013
影响因子：
--
通讯作者：
Olavarria,JaimeF
中科院分区：
文献类型：
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作者：
Laing,RobynJ;Lasiene,Jurate;Olavarria,JaimeF
众所周知，视网膜输入是必要的正常发展的纹状皮质和皮质连接，但很少有信息的作用，视网膜输入V1和周围的视觉区域之间的retinotopically组织连接的发展中发挥的作用。在几乎所有的外侧纹外区，视野的鼻颞轴的解剖学和生理学表示反映了V1中该轴的表示。为了确定纹状体-纹状体外投射的内外侧地形是否保留在去核大鼠中，我们分析了沿着V1的内外侧轴放置在不同部位的示踪剂注射产生的投射模式。我们发现，从注射部位到V1的外侧边缘的距离和在18 a区的标记模式的距离之间的相关性是强的控制和弱得多的去核。来自同一动物中成对注射的数据显示，对于给定的注射部位分离，去核大鼠的18 a区投影场的分离比对照大鼠的差异更大。我们的分析单，双示踪剂注射表明，新生儿双侧眼球摘除削弱，但不完全废除，在18 A区的中外侧地形。
It is known that retinal input is necessary for the normal development of striate cortex and its corticocortical connections, but there is little information on the role that retinal input plays in the development of retinotopically organized connections between V1 and surrounding visual areas. In nearly all lateral extrastriate areas, the anatomical and physiological representation of the nasotemporal axis of the visual field mirrors the representation of this axis in V1. To determine whether the mediolateral topography of striate‐extrastriate projections is preserved in neonatally enucleated rats, we analyzed the patterns of projections resulting from tracer injections placed at different sites along the mediolateral axis of V1. We found that the correlation between the distance from injection sites to the lateral border of V1 and the distance of the labeling patterns in area 18a was strong in controls and much weaker in enucleates. Data from pairs of injections in the same animal revealed that the separation of area 18a projection fields for a given separation of injection sites was more variable in enucleated than in control rats. Our analysis of single and double tracer injections suggests that neonatal bilateral enucleation weakens, but not completely abolishes, the mediolateral topography in area 18a.