Can we deconstruct cancer, one patient at a time?
Can we deconstruct cancer, one patient at a time?
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DOI：
10.1016/j.tig.2012.09.004
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发表时间：
2013-01
影响因子：
11.4
通讯作者：
Liakopoulou, Effie
中科院分区：
文献类型：
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作者：
Blau, C. Anthony;Liakopoulou, Effie
癌症患者面临着技术进步的指数速度和这些进步转化为临床实践的线性速度之间不断扩大的差距。缩小这一差距需要建立学习循环，将实验室和诊所紧密联系起来，使知识能够立即转移，从而使高度积极的癌症患者成为研究的真正合作伙伴。在这里，我们讨论的目标是创建一个分布式网络，旨在为精选的癌症患者和他们的肿瘤学家提供世界级的资源，然后利用这些密集监测的个体患者经验来提高对癌症如何运作的集体理解。
Patients with cancer face an ever-widening gap between the exponential rate at which technology improves and the linear rate at which these advances are translated into clinical practice. Closing this gap will require the establishment of learning loops that intimately link lab and clinic and enable the immediate transfer of knowledge, thereby engaging highly motivated patients with cancer as true partners in research. Here, we discuss the goal of creating a distributed network that aims to place world-class resources at the disposal of select patients with cancer and their oncologists, and then use these intensively monitored individual patient experiences to improve collective understanding of how cancer works.
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影响因子：
64.5
作者：
Welch JS;Ley TJ;Link DC;Miller CA;Larson DE;Koboldt DC;Wartman LD;Lamprecht TL;Liu F;Xia J;Kandoth C;Fulton RS;McLellan MD;Dooling DJ;Wallis JW;Chen K;Harris CC;Schmidt HK;Kalicki-Veizer JM;Lu C;Zhang Q;Lin L;O'Laughlin MD;McMichael JF;Delehaunty KD;Fulton LA;Magrini VJ;McGrath SD;Demeter RT;Vickery TL;Hundal J;Cook LL;Swift GW;Reed JP;Alldredge PA;Wylie TN;Walker JR;Watson MA;Heath SE;Shannon WD;Varghese N;Nagarajan R;Payton JE;Baty JD;Kulkarni S;Klco JM;Tomasson MH;Westervelt P;Walter MJ;Graubert TA;DiPersio JF;Ding L;Mardis ER;Wilson RK
通讯作者：
Wilson RK
影响因子：
7.9
作者：
Edelman, Lucas B.;Eddy, James A.;Price, Nathan D.
通讯作者：
Price, Nathan D.
影响因子：
64.8
作者：
通讯作者：
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影响因子：
64.8
作者：
Curtis, Christina;Shah, Sohrab P.;Chin, Suet-Feung;Turashvili, Gulisa;Rueda, Oscar M.;Dunning, Mark J.;Speed, Doug;Lynch, Andy G.;Samarajiwa, Shamith;Yuan, Yinyin;Graef, Stefan;Ha, Gavin;Haffari, Gholamreza;Bashashati, Ali;Russell, Roslin;McKinney, Steven;Langerod, Anita;Green, Andrew;Provenzano, Elena;Wishart, Gordon;Pinder, Sarah;Watson, Peter;Markowetz, Florian;Murphy, Leigh;Ellis, Ian;Purushotham, Arnie;Borresen-Dale, Anne-Lise;Brenton, James D.;Tavare, Simon;Caldas, Carlos;Aparicio, Samuel
通讯作者：
Aparicio, Samuel
影响因子：
64.8
作者：
通讯作者：
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