The effect of ATP-sensitive K+ channels on the electrical burst activity and insulin secretion in pancreatic beta-cells.
The effect of ATP-sensitive K+ channels on the electrical burst activity and insulin secretion in pancreatic beta-cells.
复制标题
ATP 敏感 K 通道对胰腺 β 细胞电爆发活性和胰岛素分泌的影响。
DOI：
10.1007/bf02989802
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Cook,DL
中科院分区：
文献类型：
--
作者：
Chay,TR;Kim,JR;Cook,DL
近年来，胰岛素释放β细胞的电爆发活动吸引了许多实验学家和理论家，主要是因为其功能的重要性，也因为爆发活动的非线性性质。ATP敏感性K+通道被认为在电活动和胰岛素释放中起重要作用。在本文中，我们通过计算机模拟显示了ATP和抗糖尿病药物如何延长爆发的平台分数，以及这些化学物质如何增加胰腺β细胞中的细胞内Ca2+水平。
In recent years, the electrical burst activity of the insulin releasing pancreatic β-cells has attracted many experimentalists and theoreticians, largely because of its functional importance, but also because of the nonlinear nature of the burst activity. The ATP-sensitive K+channels are believed to play an important role in electrical activity and insulin release. In this paper, we show by computer simulation how ATP and antidiabetic drugs can lengthen the plateau fraction of bursting and how these chemicals can increase the intracellular Ca2+level in the pancreatic β-cell.