Fish consumption in pregnancy and omega-3 status after birth are not associated with postnatal depression
Fish consumption in pregnancy and omega-3 status after birth are not associated with postnatal depression
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DOI：
10.1016/j.jad.2005.10.009
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发表时间：
2006-02-01
影响因子：
6.6
通讯作者：
Silvers, KM
中科院分区：
文献类型：
--
作者：
Browne, JC;Scott, KM;Silvers, KM
背景：迄今为止的研究表明，鱼类消费，ω-3多不饱和脂肪酸和抑郁症之间的关系。然而，由于方法上的限制，解释这项研究是困难的。产后妇女提供了一个很好的机会来检查这些关系，因为omega-3脂肪酸在怀孕期间从母亲转移到胎儿，并在出生后通过母乳从母亲转移到孩子。因此，新妈妈更有可能耗尽omega-3脂肪酸。我们的目的是要确定是否产前鱼消费和ω-3脂肪酸状态出生后与产后depression.Methods：80首次母亲被招募; 41人得分或超过截止两个抑郁症筛查仪器之一，39在对照组。抑郁症的诊断使用复合国际诊断访谈。在怀孕期间测量鱼的消费量，并在出生后确定抑郁和omega-3状态。Logistic回归和t检验被用来检查鱼的消费，omega-3的状态，和产后抑郁症之间的关系，同时控制已知的协variators.Results：产前鱼的消费量是不预测产后抑郁症，和产后omega-3状态与产后抑郁症。然而，产前鱼消费量预测欧米茄-3状态后birth.Limitations：产前鱼消费量仅使用食物频率问卷测量，没有参与者食用油性鱼（富含欧米茄-3）regularly.Conclusions：产后抑郁症与怀孕早期的鱼消费量或出生后的欧米茄-3状态之间没有关联。我们的研究结果很难证明omega-3多不饱和脂肪酸治疗产后抑郁症的试验是合理的。(c)2005 Elsevier B. V.保留所有权利。
Background: Research to date suggests a relationship between fish consumption, omega-3 polyunsaturated fatty acids, and depression. However, interpretation of this research is difficult due to methodological limitations. Postpartum women provide an excellent opportunity to examine these relationships because omega-3s are transferred from mother to fetus during pregnancy and from mother to child after birth through breast milk. Hence new mothers are more likely to be depleted in omega-3s. Our aim was to determine whether prenatal fish consumption and omega-3 status after birth were associated with postnatal depression.Methods: Eighty first-time mothers were recruited; 41 who scored on or over the cut-off on one of two depression-screening instruments, and 39 in the control group. Depression was diagnosed using the Composite International Diagnostic Interview. Fish consumption was measured during pregnancy, and depression and omega-3 status were determined postnatally. Logistic regression and t-tests were used to examine relationships between fish consumption, omega-3 status, and postnatal depression, while controlling for known covariates.Results: Prenatal fish consumption was not predictive of postnatal depression, and postnatal omega-3 status was not associated with postnatal depression. However, prenatal fish consumption did predict omega-3 status after birth.Limitations: Prenatal fish consumption was measured using only a food frequency questionnaire, and no participants consumed oily fish (rich in omega-3s) regularly.Conclusions: There was no association between postnatal depression and either fish consumption in early pregnancy, or omega-3 status after birth. Our findings make it difficult to justify trials of omega-3 polyunsaturated fatty acids in the treatment of postnatal depression. (c) 2005 Elsevier B.V. All rights reserved.