Women's uptake of non-invasive DNA testing following a high-risk screening test for trisomy 21 within a publicly funded healthcare system: findings from a retrospective review
Women's uptake of non-invasive DNA testing following a high-risk screening test for trisomy 21 within a publicly funded healthcare system: findings from a retrospective review
复制标题
DOI：
10.1002/pd.4544
复制
发表时间：
2015-04-01
影响因子：
3
通讯作者：
Sahota, Daljit Singh
中科院分区：
文献类型：
--
作者：
Chan, Yiu Man;Leung, Wing Cheong;Sahota, Daljit Singh
目的本研究的目的是评估 21 三体性高风险筛查结果后对非侵入性无细胞胎儿 DNA 筛查试验 (NIDT) 的采用情况方法在调整混杂因素后，评估了在 3 岁时进行高风险（足月风险 1:250）早孕期或中孕期筛查试验的香港中国女性的母亲和妊娠特征对女性检测选择的关联。 公立医院。主要结局指标是进一步检测率下降以及影响患者选择检测选项的产科和母体因素。结果与NIDT前阶段相比，NIDT的可用性为45%（P1：10'（aOR=7.36，95% CI 4.22-12.8）和1:10至1:50'（aOR=1.53，95% CI） 1.01-2.32）更多 可能会选择绒毛膜绒毛取样或羊膜穿刺术。结论NIDT降低了拒绝率。未产妇怀孕时 NIDT 的吸收率最高。 (c) 2014 年约翰威利父子公司。
ObjectiveThe objective of the study was to evaluate the uptake of non-invasive cell-free fetal DNA screening test (NIDT) after a high-risk screening result for trisomy 21MethodsAssociation between maternal and pregnancy characteristics on women's test choice was assessed after adjusting for confounding factors in Hong Kong Chinese women who had a high-risk (term risk 1:250) first-trimester or second-trimester screening test at three public hospitals. Main outcome measures were rate of declining further testing and obstetric and maternal factors impacting on patient's selection of testing options.ResultsCompared with the pre-NIDT period, the availability of NIDT resulted in a 45% (P1:10' (aOR=7.36, 95% CI 4.22-12.8) and 1:10 to 1:50' (aOR=1.53, 95% CI 1.01-2.32) were more likely to opt for chorionic villi sampling or amniocentesis.ConclusionsNIDT reduced the refusal rate. Uptake of NIDT was highest in pregnancies of nulliparous women. (c) 2014 John Wiley & Sons, Ltd.