Synthesis and biological evaluation of N alpha-hydroxysulfonyl-[Nle28,31]-CCK26-33.
Synthesis and biological evaluation of N alpha-hydroxysulfonyl-[Nle28,31]-CCK26-33.
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Nα-羟基磺酰基-[Nle28,31]-CCK26-33的合成和生物学评价。
DOI：
10.1016/0024-3205(86)90158-x
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发表时间：
1986
期刊：
影响因子：
6.1
通讯作者：
Hruby,VJ
中科院分区：
文献类型：
--
作者：
Sugg,EE;Shook,JE;Serra,M;Korc,M;Yamamura,HI;Burks,TF;Hruby,VJ
制备了两种N-末端含有乙酰基或N-末端含有羟基磺酰基的[Nle 28，31]-CCK 26 - 33类似物，并对其进行了表征。在四项生物活性测定中，这两种类似物与天然CCK 26 - 33等效，表明CCK 26 - 33类似物的N-末端硫酸化与完全生物活性相容。
Two analogues of [Nle28,31]-CCK26–33containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK26–33in four bioassays, demonstrating that N-terminal sulfation of CCK26–33analogues is compatible with full biological activity.