The obesogenic effect of high fructose exposure during early development.
The obesogenic effect of high fructose exposure during early development.
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DOI：
10.1038/nrendo.2013.108
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发表时间：
2013-08
期刊：
影响因子：
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通讯作者：
Blumberg B
中科院分区：
文献类型：
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作者：
Goran MI;Dumke K;Bouret SG;Kayser B;Walker RW;Blumberg B
致胖剂是破坏脂肪组织的功能和发育或脂质的正常代谢的化合物，导致肥胖和相关疾病的风险增加。工业和农业致肥胖物，如三丁基锡、双酚A和其他有机污染物的不利影响证据确凿。目前的证据表明，母亲的高脂肪消费促进了后代的肥胖和代谢风险增加，但对其他潜在的营养致肥剂的影响知之甚少。在过去的30年中，饮食果糖消费的广泛增加与慢性代谢和内分泌紊乱以及促进肥胖的喂养行为的改变有关。在这篇文章中，我们研究了高果糖摄入量与代谢改变和早期肥胖之间的联系。我们回顾的证据表明，高果糖暴露在胎儿，新生儿和婴儿的发展的关键时期，可以作为一个肥胖的影响终身神经内分泌功能，食欲控制，喂养行为，脂肪生成，脂肪分布和代谢系统。这些变化最终有利于肥胖和相关代谢风险的长期发展。
Obesogens are compounds that disrupt the function and development of adipose tissue or the normal metabolism of lipids, leading to an increased risk of obesity and associated diseases. Evidence for the adverse effects of industrial and agricultural obesogens, such as tributyltin, bisphenol A and other organic pollutants is well-established. Current evidence suggests that high maternal consumption of fat promotes obesity and increased metabolic risk in offspring, but less is known about the effects of other potential nutrient obesogens. Widespread increase in dietary fructose consumption over the past 30 years is associated with chronic metabolic and endocrine disorders and alterations in feeding behaviour that promote obesity. In this Perspectives, we examine the evidence linking high intakes of fructose with altered metabolism and early obesity. We review the evidence suggesting that high fructose exposure during critical periods of development of the fetus, neonate and infant can act as an obesogen by affecting lifelong neuroendocrine function, appetite control, feeding behaviour, adipogenesis, fat distribution and metabolic systems. These changes ultimately favour the long-term development of obesity and associated metabolic risk.