Replication and transmission of influenza viruses in Japanese quail
Replication and transmission of influenza viruses in Japanese quail
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DOI：
10.1016/s0042-6822(03)00094-1
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发表时间：
2003-05-25
期刊：
影响因子：
3.7
通讯作者：
Perez, DR
中科院分区：
文献类型：
--
作者：
Makarova, NV;Ozaki, H;Perez, DR
鹌鹑已成为甲型禽流感病毒在香港家禽中传播的潜在中间宿主。为了更好地理解这种可能的作用，我们测试了所有15种HA亚型的A型流感病毒在鹌鹑中的复制和传播。鹌鹑至少支持14个亚型的复制。甲型流感病毒主要在呼吸道中复制。传播实验表明，禽流感病毒在鹌鹑中的延续需要适应。从鹌鹑呼吸道中分离到低水平的猪流感病毒。没有证据表明人甲型或B型流感病毒复制。有趣的是，含有鹌鹑病毒的表面糖蛋白基因和人病毒的内部基因的人-禽重组体在鹌鹑中容易复制和传播;因此，鹌鹑可以作为具有感染人类和/或其他哺乳动物物种的潜力的流感病毒抑制剂的放大器。(C)2003 Elsevier Science（美国）。All rights reserved.
Quail have emerged as a potential intermediate host in the spread of avian influenza A viruses in poultry in Hong Kong. To better understand this possible role, we tested the replication and transmission in quail of influenza A viruses of all 15 HA subtypes. Quail supported the replication of at least 14 subtypes. Influenza A viruses replicated predominantly in the respiratory tract. Transmission experiments suggested that perpetuation of avian influenza viruses in quail requires adaptation. Swine influenza viruses were isolated from the respiratory tract of quail at low levels. There was no evidence of human influenza A or B virus replication. Interestingly, a human-avian recombinant containing the surface glycoprotein genes of a quail virus and the internal genes of a human virus replicated and transmitted readily in quail; therefore, quail could function as amplifiers of influenza virus reassortants that have the potential to infect humans and/or other mammalian species. (C) 2003 Elsevier Science (USA). All rights reserved.