Neural activation and radial diffusivity in schizophrenia: combined fMRI and diffusion tensor imaging study
Neural activation and radial diffusivity in schizophrenia: combined fMRI and diffusion tensor imaging study
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DOI：
10.1192/bjp.bp.110.081836
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发表时间：
2011-03-01
影响因子：
10.5
通讯作者：
Schloesser, Ralf G. M.
中科院分区：
文献类型：
--
作者：
Koch, Kathrin;Wagner, Gerd;Schloesser, Ralf G. M.
背景精神分裂症通常与白色物质结构的广泛变化有关。大多数研究已经调查了分数各向异性的变化，而径向或轴向扩散率的改变几乎没有研究到现在为止。目的研究径向扩散率作为一个潜在的标记髓鞘形成障碍的直接关系到异常的神经激活。方法神经激活与决策相关。在19名精神分裂症患者和20名健康对照者中研究了不确定性下的决策，并与扩散张量成像测量的径向扩散率相关。在精神分裂症组中，在不确定的情况下做出与额纹扣带回网络的激活显著降低有关。在结构上，他们表现出增加径向扩散的时间白色物质，与激活部分的frontostriatocingulate network.Conclusions目前的数据表明，相关的白色物质网络内的扩散率改变可能与精神分裂症的异常神经激活密切相关。
Background Schizophrenia is associated with often widespread changes in white matter structure. Most studies have investigated changes in fractional anisotropy, whereas alterations in radial or axial diffusivity have barely been investigated until now.Aims To investigate radial diffusivity as a potential marker of dysmyelination in direct relation to abnormalities in neural activation.Method Neural activation in association with decision-making under uncertainty was investigated in 19 people with schizophrenia and 20 healthy controls and linked to radial diffusivity as measured by diffusion tensor imaging.Results Decision-making under uncertainty was associated with a significantly decreased activation in a frontostriatocingulate network in the schizophrenia group. Structurally, they exhibited increased radial diffusivity in temporal white matter that was negatively correlated with activation in parts of the frontostriatocingulate network.Conclusions Present data indicate that altered diffusivity within relevant white matter networks may be closely linked to abnormal neural activation in schizophrenia.