Effect of temperature on the solubility of desflurane, sevoflurane, enflurane and halothane in blood.
Effect of temperature on the solubility of desflurane, sevoflurane, enflurane and halothane in blood.
复制标题
温度对地氟烷、七氟烷、安氟烷和氟烷在血液中溶解度的影响。
DOI：
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发表时间：
1997
影响因子：
9.8
通讯作者：
M A Smith
中科院分区：
文献类型：
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作者：
G G Lockwood;S. Sapsed;M A Smith
我们研究了温度对地氟烷、七氟烷、安氟烷和氟烷的血气溶解度的影响。在 29-39 摄氏度的温度范围内，在开放式比色皿或密闭烧瓶眼压计中用已知成分的气体混合物平衡血液，并使用气相色谱仪通过重复顶空分析在 37 摄氏度下测量血液中每种麻醉剂的浓度。平衡温度每降低一度，溶解度就增加 37℃ 时溶解度的 5.4%。该结果对于所有血液样本中的所有麻醉剂都是正确的，并且与其他挥发性麻醉剂的结果一致。
We have investigated the effect of temperature on the blood-gas solubility of desflurane, sevoflurane, enflurane and halothane. Blood was equilibrated with gas mixtures of known composition in open cuvette or closed flask tonometers over a temperature range of 29-39 degrees C, and the concentration of each anaesthetic in blood was measured at 37 degrees C by repeated headspace analysis using a gas chromatograph. Solubility increased by 5.4% of the solubility at 37 degrees C for each degree that equilibration temperature was reduced. This result was true for all anaesthetics in all blood samples, and is in keeping with results for other volatile anaesthetics.