Visceral hypersensitivity is associated with GI symptom severity in functional GI disorders: consistent findings from five different patient cohorts
Visceral hypersensitivity is associated with GI symptom severity in functional GI disorders: consistent findings from five different patient cohorts
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DOI：
10.1136/gutjnl-2016-312361
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发表时间：
2018-02-01
期刊：
影响因子：
24.5
通讯作者：
Whitehead, William E.
中科院分区：
文献类型：
--
作者：
Simren, Magnus;Toernblom, Hans;Whitehead, William E.
目的探讨功能性胃肠疾病（FGID）患者内脏高敏感性与胃肠症状严重程度的关系，并对心理因素和一般症状倾向进行校正。设计（IBS或功能性消化不良; n=1144），使用球囊扩张进行内脏敏感性试验（胃底、降结肠或直肠），并完成问卷调查，以评估GI症状严重程度、非GI躯体症状、焦虑和抑郁。根据疼痛/不适阈值将受试者分为敏感性三分位数。结果在所有5个队列中，随着内脏敏感性的增加，GI症状的严重程度逐渐增加，敏感性三分位数之间GI症状的严重程度有显著差异（P <0.05）。
Objective Our aim was to evaluate the association between visceral hypersensitivity and GI symptom severity in large cohorts of patients with functional GI disorder (FGID) and to adjust for psychological factors and general tendency to report symptoms.Design We included five cohorts of patients with FGIDs (IBS or functional dyspepsia; n=1144), who had undergone visceral sensitivity testing using balloon distensions (gastric fundus, descending colon or rectum) and completed questionnaires to assess GI symptom severity, non-GI somatic symptoms, anxiety and depression. Subjects were divided into sensitivity tertiles based on pain/discomfort thresholds. GI symptom severity was compared between sensitivity tertiles in each cohort and corrected for somatisation, and anxiety and depression.Results In all five cohorts, GI symptom severity increased gradually with increasing visceral sensitivity, with significant differences in GI symptom severity between the sensitivity tertiles (p