Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy volunteers
Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy volunteers
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DOI：
10.1097/jcp.0b013e3181602fab
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发表时间：
2008-02-01
影响因子：
2.9
通讯作者：
de Wit, Harriet
中科院分区：
文献类型：
--
作者：
Hamidovic, Ajna;Kang, Un Jung;de Wit, Harriet
神经递质多巴胺与药物的奖赏效应密切相关，它也被认为是动物模型中冲动行为的中介。大多数关于药物对人类冲动行为影响的研究都涉及药物对不同递质系统和不同受体亚型的复杂作用。本研究旨在表征单次给药普拉克索（一种D2/D3激动剂）对健康志愿者认知和冲动行为以及情绪指标的影响。在一项受试者内、双盲研究中，健康男性和女性（N = 10）接受安慰剂和2剂普拉克索（0.25和0.50 mg）。结果测量包括认知表现的变化，通过自动神经心理评估量表评估，与冲动行为相关的几种行为测量，包括气球焦虑风险任务，延迟折扣任务，去/不去任务，卡片坚持任务，以及通过成瘾研究中心量表，情绪状态简介和药物效应问卷评估的情绪主观评级。普拉克索降低了情绪（欣快、智力效率和精力）的积极评级，并增加了主观报告的镇静和行为镇静，这两种镇静通过自动神经心理评估量表的几项测量指标上的认知表现受损来指示。单次低至中等剂量的该药物未导致本研究中包括的行为测量的冲动反应降低。本研究中观察到的镇静样作用可能反映了药物的突触前作用。可能需要更高剂量的突触后作用来产生行为或主观的兴奋剂样效应。
The neurotransmitter dopamine is integrally involved in the rewarding effects of drugs, and it has also been thought to mediate impulsive behaviors in animal models. Most of the studies of drug effects on impulsive behaviors in humans have involved drugs with complex actions on different transmitter systems and different receptor subtypes. The present study was designed to characterize the effect of single doses of pramipexole, a D2/D3 agonist, on measures of cognitive and impulsive behavior, as well as on mood in healthy volunteers. Healthy men and women (N = 10) received placebo and 2 doses of pramipexole, 0.25 and 0.50 mg, in a within-subject, double-blinded study. Outcome measures included changes in cognitive performance, assessed by the Automated Neuropsychological Assessment Metrics, several behavioral measures related to impulsive behavior, including the Balloon Analogue Risk Task, Delay Discounting Task, Go/No-Go Task, Card Perseveration Task, and subjective ratings of mood assessed by Addiction Research Center Inventory, Profile of Mood States, and Drug Effects Questionnaire. Pramipexole decreased positive ratings of mood (euphoria, intellectual efficiency, and energy) and increased both subjectively reported sedation and behavioral sedation indicated by impaired cognitive performance on several measures of the Automated Neuropsycho logical Assessment Metrics. Single low to medium doses of this drug did not produce a decrease in impulsive responding on behavioral measures included in this study. The sedative-like effects observed in this study may reflect presynaptic actions of the drug. Higher doses with postsynaptic actions may be needed to produce either behavioral or subjective stimulant-like effects.