NEURONAL LOSS IN THE PEDUNCULOPONTINE TEGMENTAL NUCLEUS IN PARKINSON DISEASE AND IN PROGRESSIVE SUPRANUCLEAR PALSY
NEURONAL LOSS IN THE PEDUNCULOPONTINE TEGMENTAL NUCLEUS IN PARKINSON DISEASE AND IN PROGRESSIVE SUPRANUCLEAR PALSY
复制标题
DOI：
10.1073/pnas.84.16.5976
复制
发表时间：
1987-08-01
影响因子：
11.1
通讯作者：
JAVOYAGID, F
中科院分区：
文献类型：
--
作者：
HIRSCH, EC;GRAYBIEL, AM;JAVOYAGID, F
在人类和其他哺乳动物的大脑中，除了形成颅运动核团的胆碱能核团外，还有两组主要的胆碱能核团。一组位于前脑，包括Meynert基底核。第二组位于后脑中，并且包括由Mesulam等人[Mesulam，M.-Mesulam，M. M.，Mufson，E.J.，Wainer，B.H.和Levey，A.I.（1983）Neuroscience 10，1185-1201]作为胆碱能细胞群Ch 5。基底前脑胆碱能细胞群支配新皮层的广泛区域，在阿尔茨海默病和与痴呆相关的帕金森综合征中经历变性。我们在这里报告，后脑NPP Ch 5细胞群，被认为是支配许多核的锥体外系运动系统，上级丘，和无名质，经历变性的特发性帕金森病和帕金森综合征进行性核上性麻痹。这些研究结果强烈表明，在帕金森病的脑干变性不仅限于含儿茶酚胺的神经元，但胆碱能神经元的NPP也是脆弱的。这些发现进一步提高了帕金森病和进行性核上性麻痹的某些症状在这些胆碱能神经元的病理学中有其起源的可能性。
In the brains of humans and other mammals, there are two principal groups of cholinergic nuclei aside from those forming the cranial motor nuclei. One group lies in the forebrain and includes the nucleus basalis of Meynert. The second group lies in the hindbrain and includes the nucleus tegmenti pedunculopontinus (NPP), identified by Mesulam et al. [Mesulam, M.-M., Mufson, E.J., Wainer, B.H. and Levey, A.I. (1983) Neuroscience 10, 1185-1201] as cholinergic cell group Ch5. The basal forebrain cholinergic cell groups, which innervate widespread areas of the neocortex, undergo degeneration in Alzheimer disease and also in parkinsonism associated with dementia. We here report that the hindbrain NPP Ch5 cell group, thought to innervate many nuclei of the extrapyramidal motor system, the superior colliculus, and the substantia innominata, undergoes degeneration in idiopathic Parkinson disease and in the parkinsonian syndrome of progressive supranuclear palsy. These findings strongly suggest that degeneration in the brainstem in Parkinson disease is not confined to catecholamine-containing neurons, but that cholinergic neurons of the NPP are also vulnerable. The findings further raise the possibility that certain symptoms of Parkinson disease and progressive supranuclear palsy have their genesis in pathology of these cholinergic neurons.