PATTERNS OF ASTROGLIAL HYPERTROPHY AND NEURONAL DEGENERATION IN HIPPOCAMPUS OF AGED, MEMORY-DEFICIENT RATS
PATTERNS OF ASTROGLIAL HYPERTROPHY AND NEURONAL DEGENERATION IN HIPPOCAMPUS OF AGED, MEMORY-DEFICIENT RATS
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DOI：
10.1093/geronj/32.1.3
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发表时间：
1977-01-01
期刊：
影响因子：
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通讯作者：
LYNCH, G
中科院分区：
文献类型：
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作者：
LANDFIELD, PW;ROSE, G;LYNCH, G
使用改良版的卡哈尔氯化金染色法对老年和年轻费舍尔大鼠的大脑进行星形胶质细胞检测。老年动物海马中锥体细胞大量丢失，星形胶质细胞显著肥大，而前脑其他区域未见星形胶质细胞改变。海马星形胶质细胞形成模式有四个主要特点：星形胶质细胞常呈簇状；分组的星形胶质细胞通常具有相似的定向过程；小血管染色多见于锥体细胞变性区和星形胶质细胞肥大区；在一些情况下，反应性星形胶质细胞聚集在恶化区域和健康区域之间的边界。这种模式被解释为提示星形胶质细胞簇可能类似于老年斑。由于先前发现老年Fischer动物表现出保留缺陷，海马病理可能与这些动物的记忆受损有关。
The brains of aged and young Fischer rats were examined using a modified version of Cajal''s gold chloride stain for astrocytes. A sizable loss of pyramidal cells and remarkably hypertrophic astrocytes were found in the hippocampus of the aged animals, while the astrocytic changes were not seen in other forebrain regions. Four major characteristics of the pattern of hippocampal astrogliosis were noted: the astrocytes were often found grouped in clusters; grouped astrocytes often had similarly oriented processes; small blood vessels were more often stained in regions of pyramidal cell degeneration and astroglial hypertrophy; and reactive astrocytes were in several instances gathered on the border between deteriorated regions and healthier appearing areas. This pattern was interpreted to suggest that the astrocyte clusters may be analogous to senile plaques. Since the aged Fischer animals have previously been found to exhibit retention deficits, it is possible that the hippocampal pathology is related to impaired memory in these animals.