SERUM LEVELS OF INTERLEUKIN-1-ALPHA, INTERLEUKIN-1-BETA, INTERLEUKIN-6, AND TUMOR-NECROSIS-FACTOR IN PATIENTS WITH ACUTE VIRAL-HEPATITIS
SERUM LEVELS OF INTERLEUKIN-1-ALPHA, INTERLEUKIN-1-BETA, INTERLEUKIN-6, AND TUMOR-NECROSIS-FACTOR IN PATIENTS WITH ACUTE VIRAL-HEPATITIS
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DOI：
10.1093/clinids/18.2.194
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发表时间：
1994-02-01
影响因子：
11.8
通讯作者：
TAMBINI, R
中科院分区：
文献类型：
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作者：
TORRE, D;ZEROLI, C;TAMBINI, R
对急性病毒性肝炎患者血清白介素1α(IL-1α)、白介素1β(IL-1β)、白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)水平进行了检测。急性病毒性肝炎患者12例，其中急性乙型肝炎8例，急性甲型肝炎2例，急性丙型肝炎2例。急性病毒性肝炎患者血清IL-1α、IL-1β、IL-6、TNF-α水平均显著升高。在感染恢复期，4名急性乙肝患者的血清中所有细胞因子水平均降低。此外，在6个月的随访期结束时，未检测到IL-1α、IL-1β、IL-6和肿瘤坏死因子-α。我们的研究表明，IL-1α、IL-1β、IL-6和TNF-α水平的升高可能与肝炎的活动性有关，因此可能在肝细胞损伤中起一定作用。
Serum levels of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in patients with acute viral hepatitis were investigated. Twelve patients suffering from acute viral hepatitis were studied; 8 patients presented with acute hepatitis B, 2 patients with acute hepatitis A, and 2 patients with acute hepatitis C. Serum levels of IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha were significantly increased in all patients with acute viral hepatitis. Decreased serum levels of all cytokines were noted in four patients with acute hepatitis B during the recovery phase of infection. In addition, IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha were undetectable at the end of a follow-up period of 6 months. Our study shows that increased levels of IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha are probably related to hepatitis activity and thus may have some role in hepatocytic injury.