MOTOR LEARNING IN PATIENTS WITH CEREBELLAR DYSFUNCTION
MOTOR LEARNING IN PATIENTS WITH CEREBELLAR DYSFUNCTION
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DOI：
10.1093/brain/113.1.103
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发表时间：
1990-02-01
期刊：
影响因子：
14.5
通讯作者：
HALLETT, M
中科院分区：
文献类型：
--
作者：
SANES, JN;DIMITROV, B;HALLETT, M
这项研究考察了小脑功能障碍是否会导致运动学习障碍。仅有小脑萎缩或小脑萎缩合并脑干萎缩的患者和年龄匹配的正常受试者进行了两项任务，以评估技能表现的改善。第一个任务是在正常视觉引导下用手重复追踪一个不规则的几何图案，第二个任务是用反镜视觉重复追踪一个不同的几何图案。病理局限于小脑的患者表现出在正常视力下熟练执行运动的障碍，这可能与未能改变运动策略有关。脑干病变增加的患者在适应镜像倒置视力方面表现出损害。辅助实验表明，镜像倒置视觉引导的动作改善是由视觉调节的。这些结果表明，小脑及其相关的输入通路参与了运动技能的学习。
This study examined whether cerebellar dysfunction resulted in deficiencies of motor learning. Patients with cerebellar atrophy only or cerebellar atrophy combined with atrophy of the brainstem and age-matched normal subjects performed two tasks to assess improvements in skilled performance. The first task was repetitive tracing with the hand of an irregular geometric pattern with normal visual guidance, and the second task was repetitive tracing of a different geometric patttern with mirror-reversed vision. Patients with pathology limited to the cerebellum showed impairments in the skilled performance of the movement performed with normal vision that may have been related to a failure to alter movement strategy. Patients with added pathology in the brainstem exhibited impairments in adapting to mirror-reversed vision. Subsidiary experiments inicated that improvements of movements guided by mirror-reversed vision were mediated by vision. These results indicate that the cerebellum and its associated input pathways are involved in motor skill learning.