Maintaining accuracy at the expense of speed: Stimulus similarity defines odor discrimination time in mice
Maintaining accuracy at the expense of speed: Stimulus similarity defines odor discrimination time in mice
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DOI：
10.1016/j.neuron.2004.11.017
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发表时间：
2004-12-02
期刊：
影响因子：
16.2
通讯作者：
Schaefer, AT
中科院分区：
文献类型：
--
作者：
Abraham, NM;Spors, H;Schaefer, AT
通过评估气味识别时间及其对刺激相似度的依赖性来测试小鼠气味表征的时空模型。在go/ no-go操作条件反射范式下，测定了简单单分子气味和二元混合气味的识别准确率和识别时间。小鼠识别简单气味的准确率超过95%。二元混合唤起高度重叠的时空活动模式在嗅球同样很好地区分。然而，当小鼠在不到200毫秒的时间内识别简单气味时，识别高度相似的二元混合物需要70-100毫秒的时间。我们得出结论，小鼠的气味识别是快速和刺激依赖的。因此，潜在的神经元机制在快速的时间尺度上起作用，只需要短暂的气味特定时空表征就可以实现对不同气味的快速区分。然而，对高度相似刺激的精细区分需要活动的时间整合，这表明在准确性和速度之间需要权衡。
Odor discrimination times and their dependence on stimulus similarity were evaluated to test temporal and spatial models of odor representation in mice. In a go/ no-go operant conditioning paradigm, discrimination accuracy and time were determined for simple monomolecular odors and binary mixtures of odors. Mice discriminated simple odors with an accuracy exceeding 95%. Binary mixtures evoking highly overlapping spatiotemporal patterns of activity in the olfactory bulb were discriminated equally well. However, while discriminating simple odors in less than 200 ms, mice required 70-100 ms more time to discriminate highly similar binary mixtures. We conclude that odor discrimination in mice is fast and stimulus dependent. Thus, the underlying neuronal mechanisms act on a fast timescale, requiring only a brief epoch of odor-specific spatiotemporal representations to achieve rapid discrimination of dissimilar odors. The fine discrimination of highly similar stimuli, however, requires temporal integration of activity, suggesting a tradeoff between accuracy and speed.