Chemical Composition and Antiproliferative Activity of Essential Oil from the Leaves of a Medicinal Herb, Schefflera heptaphylla
Chemical Composition and Antiproliferative Activity of Essential Oil from the Leaves of a Medicinal Herb, Schefflera heptaphylla
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药草鹅掌柴叶精油的化学成分和抗增殖活性
DOI：
10.1002/ptr.2567
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发表时间：
2009-01-01
影响因子：
7.2
通讯作者：
Ooi, Vincent E. C.
中科院分区：
文献类型：
--
作者：
Li, Yao-Lan;Yeung, Chung-Man;Ooi, Vincent E. C.
七叶舍弗勒（L.）佛罗丁是一种草药，在中国南方被广泛用作抗感染的流行保健茶配方的主要成分。通过GGMS分析，鉴定出27种挥发性化合物，其中17种为单萜类或倍半萜类化合物。主要挥发性成分为单萜p -蒎烯，约占总挥发性成分的22%。该精油对MCF-7、A375和HepG2细胞均有显著的抗增殖活性，IC50值分别为7.3、7.5和6.9 μ g/mL。细胞毒性试验结果表明，(-)- β -蒎烯和(+)- β -蒎烯（可从Sigma市售）对癌细胞MCF-7、A375和HepG2也具有抗增殖活性，IC50值在147.1至264.7 μ m之间。
Schefflera heptaphylla (L.) Frodin is a medicinal herb widely used as a main ingredient or the popular health tea formulation against infections in Southern China. Twenty-seven volatile compounds were identified by GGMS analysis from the essential oil obtained from the leaves of S. heptaphylla, and 17 of them belonged to monoterpenes or sesquiterpenes. The main volatile constituent in S. heptaphylla was found to be a monoterpene, P-pinene, comprising about 22% of the total volatile components. The essential oil showed significant antiproliferative activity against three cancer cell lines, MCF-7, A375 and HepG2 cells, with IC50 values (of 7.3 mu g/mL, 7.5 mu g/mL and 6.9 mu g/mL, respectively. The result of the cytotoxicity assay indicates that (-)-beta-pinene and (+)-beta-pinene (commercially available from Sigma) also possessed antiproliferative activity against the cancer cells MCF-7, A375 and HepG2 with IC50 values ranging from 147.1 to 264.7 mu M. Copyright (c) 2008 John Wilely & Sons, Ltd.