T-Cell Project: an international, longitudinal, observational study of patients with aggressive peripheral T-cell lymphoma
T-Cell Project: an international, longitudinal, observational study of patients with aggressive peripheral T-cell lymphoma
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DOI：
10.1590/s1516-84842009000800007
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发表时间：
2009-08-01
影响因子：
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通讯作者：
Vose, Julie M.
中科院分区：
文献类型：
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作者：
Federico, Massimo;Bellei, Monica;Vose, Julie M.
外周 T 细胞淋巴瘤 (PTCL) 包括一组异质性肿瘤，这些肿瘤源自不同分化阶段的胸腺后淋巴细胞，具有不同的形态模式、表型和临床表现。 PTCL 高度多样化，反映了它们起源的细胞的多样性，目前使用世界卫生组织 (WHO) 2008 年标准进行了细分。外周T细胞淋巴瘤占西半球所有淋巴增殖性疾病的5%-10%，总体发病率为每年每10万人中0.5-2例，并且具有显着的流行病学分布，其中在亚洲发病率较高。 The clinical features of PTCL are extremely heterogeneous. PTCL 比 B 细胞非霍奇金淋巴瘤表现出更多的临床多样性，并且一些不寻常的临床特征和某些组织学亚型之间存在密切（尽管不是绝对）的关系。
Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of neoplasms that are derived from post-thymic lymphoid cells at different stages of differentiation and with different morphological patterns, phenotypes, and clinical presentations. PTCLs are highly diverse, reflecting the diverse cells from which they can originate and are currently sub-classified using World Health Organization (WHO) 2008 criteria. Peripheral T-Cell Lymphomas account for 5%-10% of all lymphoproliferative disorders in the Western hemisphere, with an overall incidence of 0.5-2 per 100,000 individuals per year, and have a striking epidemiological distribution, with higher incidence in Asia. The clinical features of PTCL are extremely heterogeneous. PTCLs express even more clinical diversity than B-cell non-Hodgkin's lymphomas, and there is a close, though not absolute, relationship between some unusual clinical features and certain histological subtypes.