Variability in prostate and seminal vesicle delineations defined on magnetic resonance images, a multi-observer, -center and -sequence study
Variability in prostate and seminal vesicle delineations defined on magnetic resonance images, a multi-observer, -center and -sequence study
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DOI：
10.1186/1748-717x-8-126
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发表时间：
2013-05-24
影响因子：
3.6
通讯作者：
Zackrisson, Bjorn
中科院分区：
文献类型：
--
作者：
Nyholm, Tufve;Jonsson, Joakim;Zackrisson, Bjorn
背景：磁共振（MR）成像作为放射治疗准备的一部分的使用正在增加。对于前列腺的描绘，几篇出版物显示与计算机断层扫描（CT）相比，使用MR的描绘变异性降低。本工作的目的是调查前列腺和精囊的内部和医生之间的划定变异性，并调查临床上使用的不同MR序列设置在五个中心参与study.Methods的影响：MR系列从五个中心，每个提供五名患者，被使用。每个中心的两名医生在25个图像集中描绘前列腺和精囊。之间的变化进行了分析，相对于整体，内部和医生间的变异性，变异性和起源的MR图像，即用于获取data.Results的MR序列之间的依赖关系：在不同方向的内部医生的变异性分别为1.3 - 1.9毫米和3 - 4毫米之间的前列腺和精囊（1标准差）。不同方向的医生间变异性在0.7 - 1.7 mm之间，前列腺和精囊的变异性大致相等。个体患者以及不同中心使用的个体成像序列的变异性存在较大差异。然而，没有迹象表明降低变异性与更高的field strength.Conclusion：整体划定变异性是较大的精囊相比，前列腺，由于一个更大的医生内的变异性。成像序列似乎对变异性有很大影响，即使是对于研究中所有中心使用的基于T2加权自旋回波序列的不同变体。
Background: The use of magnetic resonance (MR) imaging as a part of preparation for radiotherapy is increasing. For delineation of the prostate several publications have shown decreased delineation variability using MR compared to computed tomography (CT). The purpose of the present work was to investigate the intra- and inter-physician delineation variability for prostate and seminal vesicles, and to investigate the influence of different MR sequence settings used clinically at the five centers participating in the study.Methods: MR series from five centers, each providing five patients, were used. Two physicians from each center delineated the prostate and the seminal vesicles on each of the 25 image sets. The variability between the delineations was analyzed with respect to overall, intra-and inter-physician variability, and dependence between variability and origin of the MR images, i.e. the MR sequence used to acquire the data.Results: The intra-physician variability in different directions was between 1.3 - 1.9 mm and 3 - 4 mm for the prostate and seminal vesicles respectively (1 std). The inter-physician variability for different directions were between 0.7 - 1.7 mm and approximately equal for the prostate and seminal vesicles. Large differences in variability were observed for individual patients, and also for individual imaging sequences used at the different centers. There was however no indication of decreased variability with higher field strength.Conclusion: The overall delineation variability is larger for the seminal vesicles compared to the prostate, due to a larger intra-physician variability. The imaging sequence appears to have a large influence on the variability, even for different variants of the T2-weighted spin-echo based sequences, which were used by all centers in the study.