The contribution of pulmonary‐to‐systemic cardiac shunting to growth, metabolism, and recovery from exercise in Alligator mississipiensis
The contribution of pulmonary‐to‐systemic cardiac shunting to growth, metabolism, and recovery from exercise in Alligator mississipiensis
复制标题
肺-体心脏分流对密西西比鳄生长、代谢和运动恢复的贡献
DOI：
10.1096/fasebj.21.6.a1399-c
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
J. Hicks
中科院分区：
文献类型：
--
作者：
June Gwalthney;J. Eme;T. Owerkowicz;J. Blank;J. Hicks
所有非鸟类爬行动物都有混合氧合血和脱氧血（心脏分流）的能力，但心脏分流的适应意义尚未得到验证。鳄鱼的完全分开的心室允许通过封堵心脏外的左主动脉弓（LAo）来手术消除肺-体（R-L）分流的能力。通过实验去除肺-体分流能力，我们可以推断其在爬行动物中的生理功能。我们通过手术将刚孵化的美国短吻鳄（Alligator mississipiensis）的左主动脉弓（LAo）在Panizza孔的近端和远端结扎，从而消除分流。将短吻鳄分为三组：实验组（LAo闭塞）、假手术组和非手术对照组。我们研究了分流能力消除对SDA、静息代谢、力竭运动后乳酸清除率以及体重、头长、口鼻长和总长度等生长参数的影响。在手术后的前9个月，实验动物的生长显示出非显著的生长下降趋势。
All non‐avian reptiles have the capacity to mix oxygenated and deoxygenated blood (cardiac shunt), but the adaptive significance of cardiac shunting has not been tested. The fully divided ventricle of crocodilians allows for surgical elimination of the capacity for pulmonary‐to‐systemic (R‐L) shunting by occluding the left aortic arch (LAo) outside of the heart. With the experimental removal of pulmonary‐to‐systemic shunt capacity we can make inferences about its physiological function in reptiles. We surgically tied off the left aortic arch (LAo) of hatchling American alligators (Alligator mississipiensis) both proximal and distal to the foramen of Panizza, thereby eliminating shunting. The alligators were divided into three groups: experimental (occluded LAo), sham‐operated and non‐operated control. We studied the consequences of the elimination of shunt capacity on SDA, resting metabolism, lactate clearance following exhaustive exercise and the growth parameters of body mass, head length, snout‐vent length and total length. In the first nine months following surgery, growth shows a non‐significant trend of decreased growth in experimental animals.