Biomechanical properties of red blood cells in health and disease towards microfluidics
Biomechanical properties of red blood cells in health and disease towards microfluidics
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DOI：
10.1063/1.4895755
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发表时间：
2014-09-01
期刊：
影响因子：
3.2
通讯作者：
Tomaiuolo, Giovanna
中科院分区：
文献类型：
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作者：
Tomaiuolo, Giovanna
红细胞（RBC）具有独特的细胞变形能力，可以穿过各种人体微循环血管，使它们能够穿过比其直径小的毛细血管，并在血液和组织之间发挥气体载体的作用。由于越来越多的证据表明红细胞变形性在某些病理条件下受损，因此在过去几十年中，红细胞变形性的测量一直是众多研究的焦点。然而，关于健康和病理性RBC的报告目前是有限的，并且在许多情况下，没有以明确定义的细胞膜参数（例如弹性和粘度）来表示。因此，通常很难将这些结果整合到对RBC行为的基本理解以及临床应用中。这篇综述的目的是总结目前关于红细胞变形性的报道，并强调其与各种人类疾病的关系，如遗传性疾病（如：例如，在一个实施例中，球形红细胞增多症、椭圆形红细胞增多症、卵圆红细胞增多症和气孔增多症）、代谢病症（例如，例如，在一个实施例中，糖尿病、高胆固醇血症、肥胖症）、三磷酸腺苷诱导的膜变化、氧化应激和阵发性睡眠性血红蛋白尿。微流控技术已被确定为开发最先进的动态实验模型的关键，用于阐明RBC膜改变在病理条件下的意义以及这种改变在微血管流动动力学中所起的作用。(C)2014 AIP出版有限责任公司。
Red blood cells (RBCs) possess a unique capacity for undergoing cellular deformation to navigate across various human microcirculation vessels, enabling them to pass through capillaries that are smaller than their diameter and to carry out their role as gas carriers between blood and tissues. Since there is growing evidence that red blood cell deformability is impaired in some pathological conditions, measurement of RBC deformability has been the focus of numerous studies over the past decades. Nevertheless, reports on healthy and pathological RBCs are currently limited and, in many cases, are not expressed in terms of well-defined cell membrane parameters such as elasticity and viscosity. Hence, it is often difficult to integrate these results into the basic understanding of RBC behaviour, as well as into clinical applications. The aim of this review is to summarize currently available reports on RBC deformability and to highlight its association with various human diseases such as hereditary disorders (e. g., spherocytosis, elliptocytosis, ovalocytosis, and stomatocytosis), metabolic disorders (e. g., diabetes, hypercholesterolemia, obesity), adenosine triphosphate-induced membrane changes, oxidative stress, and paroxysmal nocturnal hemoglobinuria. Microfluidic techniques have been identified as the key to develop state-of-the-art dynamic experimental models for elucidating the significance of RBC membrane alterations in pathological conditions and the role that such alterations play in the microvasculature flow dynamics. (C) 2014 AIP Publishing LLC.