Rapid Evolution of Resistance and Tolerance Leads to Variable Host Recoveries following Disease-Induced Declines
Rapid Evolution of Resistance and Tolerance Leads to Variable Host Recoveries following Disease-Induced Declines
复制标题
DOI：
10.1086/729437
复制
发表时间：
2024-05-01
影响因子：
2.9
通讯作者：
Streipert，Sabrina
中科院分区：
文献类型：
--
作者：
Wilber，Mark Q.;DeMarchi，Joseph A.;Streipert，Sabrina
在不同的分类群中，正在观察到遭受严重疾病引起的下降的种群的恢复。然而，我们缺乏对受传染病影响的东道国人口和社区恢复的驱动因素和动态的理论理解。出于疾病引起的下降和新生的复苏两栖动物，我们开发了一个模型，问以下问题：不同的主机防御策略的快速进化如何影响病原体入侵和疾病引起的下降后主机的瞬时恢复轨迹？我们发现，虽然宿主的生活史可以预见是种群恢复轨迹（包括下降和恢复）变异的主要驱动因素，但使用不同宿主防御策略（即，耐受性、回避抗性和强度降低抗性）经历显著不同的恢复。在单物种宿主种群中，进化耐受性的种群恢复平均比进化抵抗力的种群慢四倍。此外，虽然使用回避抗性策略的种群具有最快的潜在恢复率，但这些种群在恢复之前可能会被困在低丰度的长期瞬态中。与此相反，种群的恢复不断发展的强度降低的阻力策略更一致的生态环境。总体而言，宿主防御策略强烈影响种群恢复的瞬时动态，并可能影响从疾病引起的下降中恢复的真实的种群的最终命运。
Recoveries of populations that have suffered severe disease-induced declines are being observed across disparate taxa. Yet we lack theoretical understanding of the drivers and dynamics of recovery in host populations and communities impacted by infectious disease. Motivated by disease-induced declines and nascent recoveries in amphibians, we developed a model to ask the following question: How does the rapid evolution of different host defense strategies affect the transient recovery trajectories of hosts following pathogen invasion and disease-induced declines? We found that while host life history is predictably a major driver of variability in population recovery trajectories (including declines and recoveries), populations that use different host defense strategies (i.e., tolerance, avoidance resistance, and intensity-reduction resistance) experience notably different recoveries. In single-species host populations, populations evolving tolerance recovered on average four times slower than populations evolving resistance. Moreover, while populations using avoidance resistance strategies had the fastest potential recovery rates, these populations could get trapped in long transient states at low abundance prior to recovery. In contrast, the recovery of populations evolving intensity-reduction resistance strategies were more consistent across ecological contexts. Overall, host defense strategies strongly affect the transient dynamics of population recovery and may affect the ultimate fate of real populations recovering from disease-induced declines.