The regulation by light of retinal necrosis and the immune response following anterior chamber inoculation of herpes simplex virus type-1.
The regulation by light of retinal necrosis and the immune response following anterior chamber inoculation of herpes simplex virus type-1.
复制标题
光对视网膜坏死的调节和前房接种 1 型单纯疱疹病毒后的免疫反应。
DOI：
10.1007/bf01379084
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发表时间：
1993
影响因子：
2.7
通讯作者：
Ferguson,TA
中科院分区：
文献类型：
--
作者：
Kahn,M;Kaplan,HJ;Ferguson,TA
在Balb/c小鼠前房注射1型单纯疱疹病毒KOS株后，出现特征性病理反应。10-14天后检查时，注射的眼睛有强烈的前段炎症，但视网膜未受影响。相反，对侧眼经历强烈和破坏性的视网膜炎，很少或没有前段受累。与这些观察结果相一致的是ACAID（前房相关免疫偏差）的诱导，其特征是DTH反应被抑制，抗体滴度正常，对HSV抗原的细胞溶解t细胞反应正常。由于我们最近已经证明ACAID在没有光的情况下不会发生（即依赖于光），我们已经检查了光对单纯疱疹视网膜炎模型的影响。当Balb/c小鼠在AC注射HSV-1之前被暗饲养或暗适应时，对侧视网膜炎被消除。在消除视网膜炎的同时，也消除了针对HSV-1抗原的ACAID。此外，如果在注射后立即将小鼠置于光照下，虽然黑暗饲养的小鼠不会发生对侧视网膜炎和ACAID，但在黑暗饲养的动物重新适应光照2周后，两者都可以重新建立。我们的研究结果表明，光进入眼睛不仅对ACAID很重要，而且对对侧单纯疱疹病毒引起的视网膜炎的发展也很重要。
Following anterior chamber injection of the KOS strain of herpes simplex virus type 1 into Balb/c mice a characteristic pathologic response occurs. When examined 10–14 days later there is intense anterior segment inflammation of the injected eye, but the retina is spared. In contrast, the contralateral eye undergoes intense and destructive retinitis with little or no involvement of the anterior segment. Coincident with these observations is the induction of ACAID (for anterior chamber associated immune deviation) which is characterized by a suppressed DTH response, normal antibody titers, and normal cytolytic T-cell responses to HSV antigens. Since we have recently demonstrated that ACAID does not take place in the absence of light (i.e., is light dependent), we have examined the effect of light on the HSV-retinitis model. When Balb/c mice are either dark-reared or dark-adapted prior to AC injection of HSV-1, contralateral retinitis is abolished. Concurrent with the abrogation of retinitis, is the elimination of ACAID to HSV-1 antigens. In addition, although contralateral retinitis and ACAID do not develop in dark-reared mice if they are placed in the light immediately following injection, both can be re-established in dark-reared animals following a 2 week period of re-adaptation to light. Our results demonstrate that the entrance of light into the eye is not only important for ACAID, but also for the development of contralateral HSV-induced retinitis.