Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
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发表时间：
2003
影响因子：
9.3
通讯作者：
D. Lee;D. Jacobs;M. Gross;C. Kiefe;J. Roseman;C. Lewis;M. Steffes
中科院分区：
文献类型：
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作者：
D. Lee;D. Jacobs;M. Gross;C. Kiefe;J. Roseman;C. Lewis;M. Steffes
背景：维持细胞谷胱甘肽浓度的γ -谷氨酰转移酶（GGT）可能是氧化应激的标志，而GGT本身可能产生氧化应激。我们进行了一项前瞻性研究，以检查血清GGT是否预测糖尿病和高血压。方法研究对象为1985-1986年间4844名18-30岁的黑人和白人男性和女性；他们在2年、5年、7年、10年和15年后再次接受了检查。第0年的GGT切点分别为12、17、25和36 U/L（总第25、50、75和90百分位；实验室异常切点分别为女性40 U/L和男性50 U/L）。我们从各自的发病率分析中删除了32名糖尿病患者和140名高血压患者。结果在比例风险回归中调整研究中心、种族、性别和年龄后，15年发生的糖尿病的0年GGT类别的风险比分别为1.0、1.6、1.7、4.0（95%可信区间为2.0-8.1）和5.5(2.7-11.1)，高血压的风险比分别为1.0、1.2、1.7（1.2-2.2）、2.3（1.7-3.2）和2.3（1.7-3.2）。对第0年饮酒、体重指数、吸烟和身体活动的额外调整减弱了这种关系，但GGT仍然是重要的预测因子。结论：处于生理正常范围内的血清GGT与糖尿病和高血压的发生有关。考虑到已知的GGT功能，这些关联与氧化应激在糖尿病和高血压风险中的作用是一致的。
BACKGROUND Gamma-glutamyltransferase (GGT), which maintains cellular concentrations of glutathione, may be a marker of oxidative stress, and GGT itself may produce oxidative stress. We performed a prospective study to examine whether serum GGT predicts diabetes and hypertension. METHODS Study participants were 4844 black and white men and women 18-30 years of age in 1985-1986; they were reexamined 2, 5, 7, 10, and 15 years later. Year 0 GGT cutpoints were 12, 17, 25, and 36 U/L (overall 25th, 50th, 75th, and 90th percentiles; the laboratory cutpoints for abnormal are 40 U/L in women and 50 U/L in men). We deleted 32 participants with prevalent diabetes and 140 participants with prevalent hypertension from the respective incidence analyses. RESULTS After adjustment for study center, race, sex, and age in proportional hazards regression, the hazard ratios across year 0 GGT categories were 1.0, 1.6, 1.7, 4.0 (95% confidence interval, 2.0-8.1), and 5.5 (2.7-11.1) for 15-year incident diabetes and 1.0, 1.2, 1.7 (1.2-2.2), 2.3 (1.7-3.2), and 2.3 (1.7-3.2) for hypertension. Additional adjustment for year 0 alcohol consumption, body mass index, cigarette smoking, and physical activity attenuated this relationship, but GGT remained a significant predictor. CONCLUSIONS Serum GGT within a range regarded as physiologically normal is associated with incident diabetes and hypertension. Considering known functionality of GGT, these associations are consistent with a role for oxidative stress in risk for diabetes and hypertension.