Resection of the Primary Colorectal Cancer Is Not Necessary in Nonobstructed Patients with Metastatic Disease
Resection of the Primary Colorectal Cancer Is Not Necessary in Nonobstructed Patients with Metastatic Disease
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DOI：
10.1634/theoncologist.2009-0022
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发表时间：
2009-01-01
期刊：
影响因子：
5.8
通讯作者：
Haller, Daniel G.
中科院分区：
文献类型：
--
作者：
Damjanov, Nevena;Weiss, Jared;Haller, Daniel G.
无症状的转移性结直肠癌患者不需要常规切除原发肿瘤。尽管一些回顾性分析表明，接受原发肿瘤切除术的患者寿命更长，但大多数这些回顾数据都是在现代多化疗出现之前，并且存在相当大的偏差，因为被认为能够接受手术的患者可能比那些不能接受手术的患者总体预后更好。除了显著延长总生存期外，目前全身化疗药物和靶向药物的联合治疗改善了局部和远处肿瘤的控制，降低了需要结肠切除术的局部肿瘤相关并发症的可能性。肿瘤学家2009；14: 963 - 969
Asymptomatic patients with metastatic colorectal cancer do not routinely need to undergo resection of the primary tumor. Although several retrospective analyses suggest that patients who undergo resection of the primary tumor live longer, most of these reviewed data prior to the advent of modern polychemotherapy and are subject to considerable bias, as patients who were considered able to undergo surgery likely had better overall prognoses than those who were not. In addition to significant prolongation of overall survival, current combinations of systemic chemotherapeutic agents and targeted agents have allowed improved local and distant tumor control, decreasing the likelihood of local tumor-related complications requiring colon resection. The Oncologist 2009; 14: 963-969