Integrated analysis of key mRNAs and lncRNAs in osteoarthritis.
Integrated analysis of key mRNAs and lncRNAs in osteoarthritis.
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DOI：
10.3892/etm.2018.6360
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发表时间：
2018-09
影响因子：
2.7
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Chen L;Zhang Y;Rao Z;Zhang J;Sun Y
骨关节炎（OA）是最常见的关节炎类型，主要见于年龄>65岁的人群。然而，OA的发生和进展的潜在机制在很大程度上仍然难以捉摸。本研究旨在鉴定OA中差异表达的mRNA和lncRNA。通过分析GSE 48556和GSE 82107数据集，在OA中总共鉴定了202个上调和434个下调的mRNA。基因本体论和京都基因百科全书和基因组通路分析表明，差异表达基因主要参与调节抗原加工和呈递、生物体间的种间相互作用、免疫应答、转录和信号转导。此外，一系列的长链非编码（lnc）RNA在OA中表达不同。为了提供新的数据，这些lncRNA在OA的分子机制和功能的作用，进行共表达分析，这表明，失调的lncRNA与转录，信号转导，免疫反应和细胞粘附。此外，蛋白质-蛋白质相互作用网络中的某些关键基因被确定。本研究为探索OA诊断和预后的潜在候选生物标志物以及新的药物靶点提供了有用的信息。
Osteoarthritis (OA) is the most common type of arthritis, observed mainly in the population aged >65 years. However, the mechanism underlying the development and progression of OA has remained largely elusive. The present study aimed to identify differentially expressed mRNAs and lncRNAs in OA. By analyzing the GSE48556 and GSE82107 datasets, a total of 202 up- and 434 downregulated mRNAs were identified in OA. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that differently expressed genes were mainly involved in regulating antigen processing and presentation, interspecies interaction between organisms, immune response, transcription and signal transduction. In addition, a series of long non-coding (lnc)RNAs were differently expressed in OA. To provide novel data on the molecular mechanisms and functional roles of these lncRNAs in OA, a co-expression analysis was performed, which revealed that the dysregulated lncRNAs were associated with transcription, signal transduction, immune response and cell adhesion. In addition, certain key genes in protein-protein interaction networks were identified. The present study provided useful information for exploring potential candidate biomarkers for the diagnosis and prognosis of OA, as well as novel drug targets.
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影响因子：
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作者：
Shi SJ;Wang LJ;Yu B;Li YH;Jin Y;Bai XZ
通讯作者：
Bai XZ
影响因子：
3.7
作者：
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通讯作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Jin, Eun-Jung
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影响因子：
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作者：
He, Xiaolu;Tan, Xueming;Fan, Zhining
通讯作者：
Fan, Zhining