Age-related impairment of quality of life after lung resection for non-small cell lung cancer
Age-related impairment of quality of life after lung resection for non-small cell lung cancer
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DOI：
10.1016/j.lungcan.2009.05.019
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发表时间：
2010-04-01
期刊：
影响因子：
5.3
通讯作者：
Kurdow, Roland
中科院分区：
文献类型：
--
作者：
Schulte, Tobias;Schniewind, Bodo;Kurdow, Roland
背景资料：非小细胞肺癌（NSCLC）切除术后的健康相关生活质量（QOL）是临床医生的首要关注点，其次是临床结局。然而，很少有研究探讨肺切除术后的生活质量，据我们所知，没有研究专门研究老年patients.Methods的生活质量：共131例非小细胞肺癌患者进行手术切除术（肺叶切除术或双叶切除术）1998年1月至2004年12月，并参加了我们的前瞻性研究。使用EORTC QLQ C-30问卷和肺特异性问卷QLQ-LC 13，在切除术前和手术后长达24个月评估患者的QOL和临床数据。生活质量，然后计算和年龄小于70岁的患者的生活质量进行了比较，年龄为70岁或以上的患者。结果：总的5年生存率为47%，并发症的发生率并没有显着差异组之间。总体而言，大多数QOL指标，包括身体功能（p < 0.001）、疼痛（p = 0.025）和呼吸困难（p < 0.001），在手术后均显著受损，并持续长达24个月。老年患者平均存活39个月，而年轻患者平均存活49个月（p = 0.18）。年轻患者的生活质量恢复到术前水平显着快于老年patients.Conclusions的生活质量：老年患者接受肺切除术的NSCLC未能完全恢复。与年轻患者相比，他们显示出达到术前QOL水平的趋势下降。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Background: Health-related quality of life (QOL) after resection of non-small cell lung cancer (NSCLC) is of primary interest to clinicians, secondary to clinical outcome. However, few studies have explored QOL following lung resection and, to our knowledge, no studies have specifically examined the QOL of elderly patients.Methods: A total of 131 patients with NSCLC underwent surgical resection (lobectomy or bilobectomy) between January 1998 and December 2004 and were enrolled in our prospective study. The patients' QOL and clinical data were assessed prior to resection and for up to 24 months after surgery using the EORTC QLQ C-30 questionnaire and the lung-specific questionnaire, QLQ-LC13. Quality of life was then calculated and the QOL of patients younger than 70 years was compared with that of patients aged 70 years or older.Results: The overall 5-year survival rate was 47%, and the rate of complications did not differ significantly between the groups. Overall, most QOL indicators, including physical function (p < 0.001), pain (p = 0.025), and dyspnea (p < 0.001) were significantly impaired after surgery and remained so for up to 24 months. Elderly patients survived for an average of 39 months, while younger patients survived for an average of 49 months (p = 0.18). The QOL of younger patients returned to preoperative levels significantly faster than did the QOL of elderly patients.Conclusions: Elderly patients who underwent lung resection for NSCLC failed to make a complete recovery. They showed a decreased tendency to achieve the preoperative level of QOL compared to younger patients. (C) 2009 Elsevier Ireland Ltd. All rights reserved.