Effects of glutamate and gamma-aminobutyric acid on spontaneously active intraocular spinal cord graft neurons.
Effects of glutamate and gamma-aminobutyric acid on spontaneously active intraocular spinal cord graft neurons.
复制标题
谷氨酸和γ-氨基丁酸对自发活动的眼内脊髓移植神经元的影响。
DOI：
10.1155/np.1991.101
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Seiger,A
中科院分区：
文献类型：
--
作者：
Broton,JG;Yezierski,RP;Seiger,A
Pieces of fetal rat lumbar spinal cord were transplanted into the anterior eye chamber of adult rat hosts. At least seven months later, extracellular single‐unit recordings of spontaneously active graft neurons were made prior to and during the superfusion of either glutamate or γ‐aminobutyric acid (GABA). Superfusion of glutamate produced an increase (five cells), decrease (three cells), or had no effect (two cells) on the firing rate of neurons tested. Superfusion of GABA decreased the firing rate of all twelve neurons tested, while superfusion of the GABA receptor antagonist bicuculline increased the firing rates of all eight neurons tested. The latency and magnitude of the responses to glutamate and GABA were not related to depth of the recording electrode below the graft surface. Together, these data suggest that the intraocular spinal cord graft is suitable for thein vivostudy of GABA and glutamate neuropharmacology.
