Estimating the diameter of airways susceptible for collapse using crackle sound.
Estimating the diameter of airways susceptible for collapse using crackle sound.
复制标题
使用爆裂声估计容易塌陷的气道直径。
DOI：
10.1152/japplphysiol.91117.2008
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Suki,Bela
中科院分区：
文献类型：
--
作者：
Majumdar,Arnab;Hantos,Zoltan;Tolnai,Jozsef;Parameswaran,Harikrishnan;Tepper,Robert;Suki,Bela
Airways that collapse during deflation generate a crackle sound when they reopen during subsequent reinflation. Since each crackle is associated with the reopening of a collapsed airway, the likelihood of an airway to be a crackle source is identical to its vulnerability to collapse. To investigate this vulnerability of airways to collapse, crackles were recorded during the first inflation of six excised rabbit lungs from the collapsed state, and subsequent reinflations from 5, 2, 1, and 0 cmH2O end-expiratory pressure levels. We derived a relationship between the amplitude of a crackle sound at the trachea and the generation number (n) of the source airway where the crackle was generated. Using an asymmetrical tree model of the rabbit airways with elastic walls, airway vulnerability to collapse was also determined in terms of airway diameterD. During the reinflation from end-expiratory pressure = 0 cmH2O, the most vulnerable airways were estimated to be centered atn= 12 with a peak. Vulnerability in terms ofDranged between 0.1 and 1.3 mm, with a peak at 0.3 mm. During the inflation from the collapsed state, however, vulnerability was much less localized to a particularnorD, with maximum values ofn= 8 andD= 0.75 mm. Numerical simulations using a tree model that incorporates airway opening and closing support these conclusions. Thus our results indicate that there are airways of a given range of diameters that can become unstable during deflation and vulnerable to collapse and subsequent injury.
