Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives.
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives.
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肿瘤微环境中癌症相关成纤维细胞和免疫细胞之间的串扰：新发现和未来前景。
DOI：
10.1186/s12943-021-01428-1
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发表时间：
2021-10-11
期刊：
影响因子：
37.3
通讯作者：
Shi S
中科院分区：
文献类型：
--
作者：
Mao X;Xu J;Wang W;Liang C;Hua J;Liu J;Zhang B;Meng Q;Yu X;Shi S
肿瘤相关成纤维细胞(CAF)是一类起源于细胞、表型和功能异质性的间质细胞群，是肿瘤微环境(TME)的重要组成部分。活化的CAF可通过多种途径促进肿瘤生长、血管生成、侵袭和转移，以及细胞外基质(ECM)重塑甚至化疗耐药。许多先前的研究证实了CAF和肿瘤细胞之间的相互作用在肿瘤的发生和发展中的关键作用。然而，近年来，CAF与肿瘤免疫微环境(TIME)的相互作用被认为是促进肿瘤进展的另一个关键因素。时间主要由肿瘤胰岛中不同的免疫细胞群组成，并与TME的抗肿瘤免疫状态高度相关。CAF在一段时间内通过分泌各种细胞因子、生长因子、趋化因子、外切体和其他效应分子与肿瘤浸润性免疫细胞和其他免疫成分相互作用，从而形成免疫抑制的TME，使癌细胞能够逃避免疫系统的监视。深入研究CAF与免疫微环境的相互作用，特别是CAF与免疫细胞之间复杂的联系机制，可能为后续的靶向免疫治疗提供新的策略。在此，我们就CAF与浸润性免疫细胞之间的直接和间接相互作用的最新研究进展作一综述，并进一步总结CAF在TME中可能的免疫抑制机制。此外，我们还介绍了目前相关的CAF靶向免疫治疗方法，并对CAF研究的未来进行了展望。
Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote tumor growth, angiogenesis, invasion and metastasis, along with extracellular matrix (ECM) remodeling and even chemoresistance. Numerous previous studies have confirmed the critical role of the interaction between CAFs and tumor cells in tumorigenesis and development. However, recently, the mutual effects of CAFs and the tumor immune microenvironment (TIME) have been identified as another key factor in promoting tumor progression. The TIME mainly consists of distinct immune cell populations in tumor islets and is highly associated with the antitumor immunological state in the TME. CAFs interact with tumor-infiltrating immune cells as well as other immune components within the TIME via the secretion of various cytokines, growth factors, chemokines, exosomes and other effector molecules, consequently shaping an immunosuppressive TME that enables cancer cells to evade surveillance of the immune system. In-depth studies of CAFs and immune microenvironment interactions, particularly the complicated mechanisms connecting CAFs with immune cells, might provide novel strategies for subsequent targeted immunotherapies. Herein, we shed light on recent advances regarding the direct and indirect crosstalk between CAFs and infiltrating immune cells and further summarize the possible immunoinhibitory mechanisms induced by CAFs in the TME. In addition, we present current related CAF-targeting immunotherapies and briefly describe some future perspectives on CAF research in the end.
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DOI：
10.1073/pnas.1600363113
发表时间：
2016-07-05
影响因子：
11.1
作者：
Arina, Ainhoa;Idel, Christian;Schreiber, Hans
通讯作者：
Schreiber, Hans
影响因子：
10.3
作者：
Brennen, W. Nathaniel;Rosen, D. Marc;Denmeade, Samuel R.
通讯作者：
Denmeade, Samuel R.
影响因子：
7.7
作者：
Barrett RL;Puré E
通讯作者：
Puré E
DOI：
10.1039/c5ib00040h
发表时间：
2015-10
期刊：
Integrative biology : quantitative biosciences from nano to macro
影响因子：
--
作者：
Acerbi I;Cassereau L;Dean I;Shi Q;Au A;Park C;Chen YY;Liphardt J;Hwang ES;Weaver VM
通讯作者：
Weaver VM
影响因子：
4.7
作者：
Bellone M;Calcinotto A
通讯作者：
Calcinotto A