In gender-based outcomes, sex hormones may be important but it is in the genes*.
In gender-based outcomes, sex hormones may be important but it is in the genes*.
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在基于性别的结果中，性激素可能很重要，但它存在于基因中*。
DOI：
10.1097/ccm.0000000000000268
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发表时间：
2014
影响因子：
8.8
通讯作者：
Spolarics,Zoltán
中科院分区：
文献类型：
--
作者：
Spolarics,Zoltán
重症监护医学www. ccmjournal。org 1295变体）。如果IRAK 1变异至少部分地促成了Guidry队列的临床过程，那么它对男性的影响是女性的四倍（25% vs 6.3%）。此外，由于创伤队列中男性人数较多，该百分比差异导致256名男性患者受影响，但创伤队列中仅24名女性患者受影响（10倍差异）。IRAK 1变体在男性中的过度表达与研究中观察到的入院细胞因子水平升高、肺部感染更频繁和死亡率恶化一致（1，7，12）。因此，Guidry等人（1）的研究以及其他类似设计的研究中所证明的女性优势很可能至少部分相关，IRAK 1多态性只是一个例子，其他X-染色体多态性也是一个例子。连锁的免疫调节遗传变异预计会通过增加男性中X连锁风险等位基因的代表性来促进或混淆观察结果。同时，尽管IRAK 1变异体的细胞嵌合体似乎在急性炎症中是有利的，但其他X连锁风险等位基因的嵌合体可能是不利的。如果是这样的话，那么马赛克状态将削弱或改变女性性别优势的方向。为了支持这一观点，X染色体嵌合体与女性对自身免疫性疾病的易感性增加有关（14，15）。
Critical Care Medicine www. ccmjournal. org 1295 variant). If the IRAK1 variant contributed, at least in part, to the clinical course of the Guidry cohort, and it likely did, then its impact was four-fold greater on men than women (25% vs 6.3%). Furthermore, due to the greater number of men in the trauma cohort, this percentage difference accounts to 256 affected male patients but only 24 affected female patients in the trauma cohort (10-fold difference). This overrepresentation of the IRAK1 variant in men is consistent with the increased admission cytokine levels, more frequent pulmonary infections, and worsened mortality observed in the study (1, 7, 12). Thus, it is quite possible that the female advantage demonstrated in the study by Guidry et al (1), and presumably other studies of similar design, is related, at least in part, to the increased representation of the IRAK1 variant among men in the cohort.IRAK1 polymorphisms is only one example and other X-linked immunomodulatory genetic variants are expected to contribute to or confound the observations through increased representation of X-linked risk alleles in men. At the same time, whereas cellular mosaicism for the IRAK1 variant seems to be advantageous in acute inflammation, mosaicism for other X-linked risk alleles may be disadvantageous. If this were the case, then mosaic status would blunt or switch the direction of female sex advantage. In support of this notion, X chromosome mosaicism has been implicated in increased female susceptibility to autoimmune diseases (14, 15).
影响因子：
4
作者：
Forsdyke, Donald R.
通讯作者：
Forsdyke, Donald R.
严重受伤后的种族差异和基于性别的结果差异。
影响因子：
5.2
作者：
Sperry,JasonL;Vodovotz,Yoram;Ferrell,RobertE;Namas,Rami;Chai,Yi-Min;Feng,Qi-Ming;Jia,Wei-Ping;Forsythe,RaquelM;Peitzman,AndrewB;Billiar,TimothyR
通讯作者：
Billiar,TimothyR
两个独立人群中白细胞介素 1 受体相关激酶 (IRAK1) 基因中的单倍型 (196Phe/532Ser) 与低径向骨矿物质密度的关联
影响因子：
6.2
作者：
R. Ishida;M. Emi;Y. Ezura;H. Iwasaki;H. Yoshida;Takao Suzuki;T. Hosoi;S. Inoue;M. Shiraki;Hiromoto Ito;H. Orimo
通讯作者：
H. Orimo