Gene transfer and genome plasticity in Thermotoga maritima, a model hyperthermophilic species
Gene transfer and genome plasticity in Thermotoga maritima, a model hyperthermophilic species
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DOI：
10.1128/jb.187.14.4935-4944.2005
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发表时间：
2005-07-01
影响因子：
3.2
通讯作者：
Nelson, KE
中科院分区：
文献类型：
--
作者：
Mongodin, EF;Hance, IR;Nelson, KE
极端嗜热细菌海栖热袍菌MSB 8的基因组序列为细菌和古细菌物种之间的横向基因转移事件提供了证据。为了估计整个热袍菌目的基因组多样性的程度，启动了比较基因组杂交研究，以将9个热袍菌菌株与测序的T. maritima MSB 8.许多差异可能与基板利用模式，这是最有可能的环境生态位，这些个别物种占据的反映。对一些预测的可变区的详细分析证明了基因的完整盒的缺失/插入以及基因重排和基因内DNA的插入的许多实例，其中C或N末端被保留。虽然该谱系中的基因转移机制仍有待阐明，但这项分析表明可能与重复元素有关，并强调了猖獗的遗传交换对这些物种可能带来的好处。
The genome sequence of the hyperthermophilic bacterium Thermotoga maritima MSB8 presents evidence for lateral gene transfer events between bacterial and archaeal species. To estimate the extent of genomic diversity across the order Thermotogales, a comparative genomic hybridization study was initiated to compare nine Thermotoga strains to the sequenced T. maritima MSB8. Many differences could be associated with substrate utilization patterns, which are most likely a reflection of the environmental niche that these individual species occupy. A detailed analysis of some of the predicted variable regions demonstrates many examples of the deletion/insertion of complete cassettes of genes and of gene rearrangements and insertions of DNA within genes, with the C or N terminus being retained. Although the mechanism for gene transfer in this lineage remains to be elucidated, this analysis suggests possible associations with repetitive elements and highlights the possible benefits of rampant genetic exchange to these species.