PLASMA-MEMBRANE PHOSPHOLIPID AND CHOLESTEROL DISTRIBUTION OF SKIN FIBROBLASTS FROM DRUG-NAIVE PATIENTS AT THE ONSET OF PSYCHOSIS
PLASMA-MEMBRANE PHOSPHOLIPID AND CHOLESTEROL DISTRIBUTION OF SKIN FIBROBLASTS FROM DRUG-NAIVE PATIENTS AT THE ONSET OF PSYCHOSIS
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DOI：
10.1016/0920-9964(94)90048-5
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发表时间：
1994-10-01
影响因子：
4.5
通讯作者：
SCHEFFER, R
中科院分区：
文献类型：
--
作者：
MAHADIK, SP;MUKHERJEE, S;SCHEFFER, R
本文比较了未用药精神病患者成纤维细胞膜主要磷脂、胆固醇和胆固醇酯含量与正常对照组。提取总膜脂，并在高效薄层色谱上分离单个脂质。采用光密度扫描法定量脂质条带的含量，并与标准品进行比较。成纤维细胞中总磷脂、磷脂酰丝氨酸、磷脂酰肌醇和磷脂酰乙醇胺含量均显著低于正常对照组（P分别< 0.001、< 0.005、<0.05、< 0.05）。成纤维细胞中总胆固醇含量和胆固醇酯含量也显著降低（P分别< 0.005，< 0.001）。这些变化与年龄或性别差异无关。这些数据支持这样的假设，即精神分裂症与膜脂代谢紊乱有关，并且这早于精神病的发作。
Contents of plasma membrane major phospholipids, cholesterol, and cholesteryl esters of fibroblasts from drug-naive psychotic patients were compared with those from normal controls. Total membrane lipids were extracted and individual lipids were separated on high-performance thin-layer chromatography. The contents of lipid bands were quantitated by densitometric scanning and comparing with standards. Contents of total phospholipids as well as phosphatidylserine, phosphatidylinositol and phosphatidylethanolamine were significantly lower in fibroblasts from patients than in those from normal controls (P < 0.001, < 0.005, < 0.05, < 0.05 respectively). Total cholesterol fraction and cholesteryl esters were also significantly lower in fibroblasts from patient (P < 0.005, < 0.001 respectively). These changes were not related to differences in age or sex. These data support the hypothesis that schizophrenia is associated with disordered membrane lipid metabolism, and that this predates the onset of psychosis.