Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of Italian-Caucasian nondiabetic subjects
Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of Italian-Caucasian nondiabetic subjects
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DOI：
10.2337/db06-0063
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发表时间：
2006-07-01
期刊：
影响因子：
7.7
通讯作者：
Sesti, Giorgio
中科院分区：
文献类型：
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作者：
Andreozzi, Francesco;Laratta, Emanuela;Sesti, Giorgio
我们研究了血浆白细胞介素-6 （IL-6）水平与胰岛素敏感性和胰岛素分泌之间的关系。采用正糖-高胰岛素钳法评价胰岛素敏感性，静脉葡萄糖耐量试验测定一期胰岛素分泌。空腹血浆IL-6浓度与胰岛素刺激的葡萄糖处置率呈负相关（P = 0.001）。在调整性别、年龄和BMI后，相关性仍有统计学意义，但有所减弱（P < 0.03）；在额外调整游离脂肪酸（FFAs）后，观察到进一步的衰减，但保持统计学意义（P < 0.044）。空腹血浆IL-6浓度与急性胰岛素反应（AIR）的一期胰岛素分泌呈正相关（P = 0.001）。在调整性别、年龄和BMI后，相关性仍然显著（P = 0.003）。为了估计血浆IL-6水平对AIR的独立贡献，我们在一个包括性别、年龄、BMI、腰臀比、FFAs和胰岛素刺激葡萄糖处理的模型中进行了逐步线性回归分析。只有胰岛素敏感性和血浆IL-6浓度与AIR独立相关，分别占其变异的19.0%和5.2%。这些数据表明，IL-6与2型糖尿病的两种病理生理成分，即胰岛素抵抗和胰岛素分泌相互关联。
We have investigated the relationships between plasma interleukin-6 (IL-6) levels and insulin sensitivity and insulin secretion in a cohort of Italian-Caucasian glucose-tolerant subjects. Insulin sensitivity was assessed by euglycemic-hyperinsulinemic clamp, and first-phase insulin secretion was measured by intravenous glucose tolerance test. Fasting plasma IL-6 concentration was negatively correlated with the rate of insulin-stimulated glucose disposal (M) (P = 0.001). The correlation remained statistically significant, while attenuated, after adjusting for sex, age, and BMI (P < 0.03); after an additional adjustment for free fatty acids (FFAs), a further attenuation was observed, but statistical significance was maintained (P < 0.044). Fasting plasma IL-6 concentration was positively correlated with first-phase insulin secretion assessed as acute insulin response (AIR) (P = 0.001). The correlation remained significant after adjusting for sex, age, and BMI (P = 0.003). To estimate the independent contribution of plasma IL-6 levels to AIR, we carried out forward stepwise linear regression analysis in a model that included sex, age, BMI, waist-to-hip ratio, FFAs, and insulin-stimulated glucose disposal. Only insulin sensitivity and plasma IL-6 concentration were independently associated with AIR, accounting, respectively, for 19.0 and 5.2% of its variation. These data indicate that IL-6 is associated in a reciprocal manner with the two pathophysiological components of type 2 diabetes, i.e., insulin resistance and insulin secretion.