Poststroke neurogenesis: Emerging principles of migration and localization of immature neurons
Poststroke neurogenesis: Emerging principles of migration and localization of immature neurons
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DOI：
10.1177/1073858407309545
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发表时间：
2008-08-01
期刊：
影响因子：
5.6
通讯作者：
Carmichael, S. T.
中科院分区：
文献类型：
--
作者：
Ohab, J. J.;Carmichael, S. T.
中风诱导室下区新生神经元的增殖、这些未成熟神经元远离SVZ的迁移以及在梗塞周围组织内的定位。这3个增殖、迁移和定位过程构成了卒中后神经发生中不同的空间和时间区域，具有不同的分子和细胞-细胞信号环境。中风后未成熟神经元迁移与血管和星形胶质细胞过程密切相关，这一过程涉及基质金属蛋白酶。这种中风后的迁移与正常的神经母细胞在吻侧迁移流中的迁移具有相似的特征。不成熟的神经元定位在梗死周围皮层的神经血管龛中，其中神经发生通过血管因子SDF-1和血管生成素-1与血管生成因果相关。其他血管和神经生长因子也与中风后梗死周围组织中的成神经细胞定位有关，包括促红细胞生成素。大多数关于中风后神经发生的数据来自实验室啮齿动物，与正常的野生啮齿动物相比，这些啮齿动物可能具有异常或钝化程度的神经发生和神经可塑性。这可能会影响中风后神经发生的原则从小鼠到人类的翻译应用。
Stroke induces proliferation of newly born neurons in the subventricular zone, migration of these immature neurons away from the SVZ, and localization within peri-infarct tissues. These 3 processes of proliferation, migration, and localization constitute distinct spatial and temporal zones within poststroke neurogenesis with distinct molecular and cell-cell signaling environments. Immature neurons migrate after stroke in close association with blood vessels and astrocytic processes, in a process that involves matrix metalloproteinases. This poststroke migration shares similar features with normal neuroblast migration in the rostral migratory stream. Immature neurons localize in the peri-infarct cortex in a neurovascular niche where neurogenesis is causally linked to angiogenesis through the vascular factors SDF-1 and angiopoietin-1. Other vascular and neuronal growth factors have also been linked to poststroke neuroblast localization in peri-infarct tissue, including erythropoietin. Most data on poststroke neurogenesis derive from laboratory rodents, which may have an abnormal or blunted degree of neurogenesis and neuroplasticity compared to normal, wild rodents. This will likely affect translational application of the principles of poststroke neurogenesis from mouse to man.