Herpesvirus infections in solid organ transplant patients at high risk of primary cytomegalovirus disease
Herpesvirus infections in solid organ transplant patients at high risk of primary cytomegalovirus disease
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DOI：
10.1086/466532
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发表时间：
2005-10-15
影响因子：
6.4
通讯作者：
Paya, CV
中科院分区：
文献类型：
--
作者：
Razonable, RR;Brown, RA;Paya, CV
对263例接受口服更昔洛韦或缬更昔洛韦预防的实体器官移植患者进行了5种人类疱疹病毒（HHV-6、HHV-7、HHV-8、水痘带状疱疹病毒[VZV]和EB病毒[EBV]）感染的流行病学调查。HHV-6 B DNA血症不常见，未观察到HHV-6A DNA血症，HHV-7 DNA血症普遍存在。HHV-6和HHV-7 DNA血症与巨细胞病毒（CMV）疾病无显著相关性，尽管在HHV-6 DNA血症患者中观察到CMV疾病发生率较高的趋势。未检出VZV和HHV-8 DNA血症。EBV感染是常见的，尽管高水平EBV DNA血症的发生率较低，特别是在接受缬更昔洛韦预防的患者中。在移植后12个月内未观察到EBV相关的移植后淋巴组织增生性疾病。与历史数据相比，本研究的数据表明，抗病毒预防可能会降低HHV-6、HHV-8、VZV和EBV感染的DNA血症的发生率、患病率或水平，但对HHV-7感染没有影响。
The epidemiology of infections with 5 human herpesviruses ( HHVs) (HHV-6, HHV-7, HHV-8, varicella zoster virus [VZV], and Epstein-Barr virus [EBV]) was investigated during the first year after solid organ transplantation in 263 patients who received oral ganciclovir or valganciclovir prophylaxis. HHV-6B DNAemia was uncommon, HHV-6A DNAemia was not observed, and HHV-7 DNAemia was prevalent. HHV-6 and HHV-7 DNAemia were not significantly associated with cytomegalovirus (CMV) disease, although a trend toward higher incidence of CMV disease was observed in HHV-6 DNAemic patients. VZV and HHV-8 DNAemia were not detected. EBV infection was common, although incidence of high-level EBV DNAemia was low, especially in patients who received valganciclovir prophylaxis. EBV-related posttransplant lymphoproliferative disease was not observed up to 12 months after transplantation. Compared with historic data, data from the present study suggest that antiviral prophylaxis may lower the incidence, prevalence, or level of DNAemia for infection with HHV-6, HHV-8, VZV, and EBV but not for infection with HHV-7.