BIODISTRIBUTION OF TRITIATED BENZOPORPHYRIN DERIVATIVE (H-3-BPD-MA), A NEW POTENT PHOTOSENSITIZER, IN NORMAL AND TUMOR-BEARING MICE
BIODISTRIBUTION OF TRITIATED BENZOPORPHYRIN DERIVATIVE (H-3-BPD-MA), A NEW POTENT PHOTOSENSITIZER, IN NORMAL AND TUMOR-BEARING MICE
复制标题
DOI：
10.1016/1011-1344(90)80008-l
复制
发表时间：
1990-04-15
影响因子：
5.4
通讯作者：
LEVY, JG
中科院分区：
文献类型：
--
作者：
RICHTER, AM;CERRUTISOLA, S;LEVY, JG
The biodistribution of a new and very potent photosensitizer, benzoporphyrin derivative-monoacid, ring A (BPD-MA), was determined in normal and P815 (mastocytoma) or M1 (rhabdomyosarcoma) tumor-bearing DBA-2J mice. A dose of 80 .mu.g of 3H-BPD-MA was determined at 3, 24, 48, 72, 96 and 168 h post injection. The following tissues were tested: blood, brain, heart, intestine, kidney, lung, liver, muscle, skin, stomach, spleen, thymus and tumor. The biodistribution of 3H-BPD-MA in normal and tumor-bearing mice was comparable overall. 3H-BPD-MA localized in tumors better than in other tissues except kidney, liver and spleen. The tumor to tissue ratios were in the range 1.5-3 at 24 h post injection and increased further during the next 72 h. The highest levels of 3H-BPD-MA were observed in all tissues at 3 h post injection and decreased rapidly during the first 24 h. After 24 h the clearacne from tissues was rather slow. The preliminary clearance data obtained in a group of five normal mice indicated that the majority of the injected dose (60%) cleared from the body via the bile and feces, while only about 4% cleared via kidneys and urine. Studies in which 3H-BPD-MA was extracted from tumor, kidney and liver 3 and 24 h after injection showed that, at 3 h, all the photosensitizing activity in tumor was retained. At 24 h only 39% of the activity was retained and considerably less active material was present in liver and kidney.
