Association between metabolic syndrome and risk of stroke: A meta-analysis of cohort studies
Association between metabolic syndrome and risk of stroke: A meta-analysis of cohort studies
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DOI：
10.1159/000131672
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Zhang, Shihong
中科院分区：
文献类型：
--
作者：
Li, Wei;Ma, Dongrui;Zhang, Shihong
背景：我们的目的是通过荟萃分析研究代谢综合征与卒中风险之间的关系。研究方法：检索截至2007年7月的电子数据库，以确定检查代谢综合征与中风风险之间关系的前瞻性队列研究。两名评审员独立评估合格性，并使用标准化表格从已发表的研究中收集数据。研究质量采用Newcastle-Ottawa量表进行评估。结果：我们发现了13项合格的研究，包括92，732名参与者。与无代谢综合征的个体相比，代谢综合征受试者卒中风险增加1.6倍（95%CI，1.48-1.75）。在使用世界卫生组织定义的研究中，与代谢综合征相关的卒中相对风险为2.2，在使用成人治疗组III定义的研究中为1.6，但差异无统计学意义。结论：代谢综合征是脑卒中的重要危险因素。代谢综合征的诊断可能在临床管理中被证明是有用的，其要素最终应成为减少普通人群卒中负担的重要治疗靶点。版权所有（C）2008 S. Karger AG，巴塞尔。
Background: Our purpose was to investigate the association between metabolic syndrome and risk of stroke by meta-analysis. Methods: Electronic databases through July 2007 were searched to identify prospective cohort studies that examined the association between metabolic syndrome and risk of stroke. Two reviewers independently assessed eligibility and used a standardized form to collect data from published studies. The study quality was assessed by the Newcastle-Ottawa Scale. Results: We found 13 eligible studies that included 92,732 participants. Compared to individuals without metabolic syndrome, subjects with metabolic syndrome had a 1.6-fold increased risk of stroke (95% CI, 1.48-1.75). The relative risk of stroke associated with metabolic syndrome was 2.2 in the studies using the World Health Organization definition and 1.6 in those using the Adult Treatment Panel III definition, but the difference was not statistically significant. Conclusions: This analysis shows that metabolic syndrome is an important risk factor for incident stroke. A diagnosis of metabolic syndrome may prove useful in clinical management, and its elements should ultimately become important therapeutic targets for the reduction of the stroke burden in the general population. Copyright (C) 2008 S. Karger AG, Basel.